3-(2,4-dimethoxybenzylidene)anabaseine

Uses

GTS-21 has been used:

• as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages
• to test its protective effect on the renal injury induced by lipopolysaccharide (LPS)
• to test its effect on microvascular inflammation?in endotoxemia induced by LPS

Biochem/physiol Actions

GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.