ChemicalBook > CAS DataBase List > 5-Hydroxytryptophan


5-Hydroxytryptophan Structure
  • CAS No.56-69-9
  • Chemical Name:5-Hydroxytryptophan
  • CBNumber:CB0110022
  • Molecular Formula:C11H12N2O3
  • Formula Weight:220.22
  • MOL File:56-69-9.mol
5-Hydroxytryptophan Property
  • Melting point 298-300°C
  • Boiling point 361.16°C (rough estimate)
  • Density 1.484
  • refractive index 1.5200 (estimate)
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • pka 2.22±0.10(Predicted)
  • form solid
  • Water Solubility Soluble in water (4 mg/ml at 25°C), methanol.
  • Merck 14,4847
  • BRN 88199
  • CAS DataBase Reference 56-69-9(CAS DataBase Reference)
  • EWG's Food Scores 1
  • EPA Substance Registry System Tryptophan, 5-hydroxy- (56-69-9)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
5-Hydroxytryptophan Price More Price(30)
  • Brand: Sigma-Aldrich
  • Product number: 797103
  • Product name : 5-Hydroxy-DL-tryptophan
  • Purity: 
  • Packaging: 5mg
  • Price: $110
  • Updated: 2022/05/15
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A12237
  • Product name : DL-5-Hydroxytryptophan, 99%
  • Purity: 
  • Packaging: 1g
  • Price: $54.2
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: A12237
  • Product name : DL-5-Hydroxytryptophan, 99%
  • Purity: 
  • Packaging: 5g
  • Price: $227
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: H975700
  • Product name : 5-HydroxyTryptophan
  • Purity: 
  • Packaging: 5g
  • Price: $140
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TRC
  • Product number: H975700
  • Product name : 5-HydroxyTryptophan
  • Purity: 
  • Packaging: 50mg
  • Price: $65
  • Updated: 2021/12/16
  • Buy: Buy

5-Hydroxytryptophan Chemical Properties,Usage,Production

  • Description 5-Hydroxytryptophan (5-HTP) is an aromatic amino acid naturally produced by the body from the essential amino acid L-tryptophan (LT). Produced commercially by extraction from the seeds of the African plant, Griffonia simplicifolia, 5-HTP has been used clinically for over 30 years. The clinical efficacy of 5-HTP is due to its ability to increase production of serotonin in the brain.
  • Chemical Properties Off-White to Pale Beige Solid
  • Originator Levotonine,Panmedica,France,1973
  • Uses 5-Hydroxytryptophan (5-HTP) is an intermediate in the natural synthesis of the essential amino acid, tryptophan, to serotonin. Clinical studies suggest that 5-HTP supports healthy serotonin levels. In the body, 5-HTP converts to serotonin with the enzymatic removal of a carboxyl group (COOH). Serotonin is an important neurotransmitter involved in the regulation of endocrine and brain activity responsible for emotion, appetite and sleep/wake cycles.?
  • Uses A metabolite of Tryptophan. 5-Hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function.
  • Application 5-hydroxytryptophan is a dietary supplement made from the seeds of the African plant Griffonia simplicifolia.
    5-hydroxytryptophan has been used in alternative medicine as a possibly effective aid in treating depression or fibromyalgia.
    Other uses not proven with research have included insomnia, alcohol withdrawal, headaches, premenstrual syndrome, binge-eating related to obesity, attention deficit disorder, and muscle spasms in the mouth.
    5-hydroxytryptophan is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
  • Manufacturing Process Preparation of 5-Hydroxytryptophan: 0.4 gram palladium chloride and 1.7 grams acid-washed charcoal were suspended in 157 ml water and hydrogenated at room temperature and atmospheric pressure until no further hydrogen uptake occurred. A suspension of 14.2 grams 5- benzyloxytryptophan in 175 ml ethyl alcohol was added and the mixture hydrogenated under similar conditions. A hydrogen uptake slightly in excess of theory was obtained. The suspension was warmed for a few minutes on the steam bath and filtered hot. The filter-cake was washed with hot water (3 x 20 ml) and the filtrate evaporated to 20 ml under reduced pressure in a nitrogen atmosphere.
    The resultant mass of colorless crystals was triturated with 250 ml ice-cold ethyl alcohol under hydrogen, filtered, and washed with cold ethyl alcohol (2 x 15 ml). The 5-hydroxytryptophan (6.9 grams, 69%) had MP (sealed evacuated tube) 288°C, with softening, finally melting at 249° to 247°C (decomposition). Concentration of the liquors under reduced pressure in a nitrogen atmosphere, and trituration as before, gave a second crop (0.9 gram, 9%). The combined crops (7.8 grams) were dissolved in 120 ml hot water, charcoal added, and the mixture filtered hot. The filtrate was concentrated in a nitrogen atmosphere under reduced pressure and ethyl alcohol added. The 5-hydroxytryptophan then crystallized as colorless microneedles (6.5 grams,65%), had MP (sealed evacuated tube) 290°C, with slight softening, finally melting at 295° to 297°C (decomposition).
  • Therapeutic Function Antidepressant, Antiepileptic
  • Biochem/physiol Actions Immediate precursor of serotonin; L-aromatic amino acid decarboxylase substrate.
  • Source 5-HTP is derived from the Griffonia simplicifolia plant. Hypo-allergenic plant fiber is derived from pine cellulose.
  • Mode of action 5-Hydroxytryptophan acts primarily by increasing levels of serotonin within the central nervous system. Other neurotransmitters and CNS chemicals, such as melatonin, dopamine, norepinephrine, and beta-endorphin have also been shown to increase following oral administration of 5-HTP. This ability to increase not only serotonin levels in the brain, but also dopamine and norepinephrine, allows 5-HTP to produce some significant and unique effects on brain chemistry and on serotonin-related conditions which other substances, including LT, cannot duplicate.?
5-Hydroxytryptophan Preparation Products And Raw materials
Raw materials
Preparation Products
  • Supplier:
    career henan chemical co
  • Tel:+86-0371-86658258
  • Country:China
  • ProdList:29960
  • Advantage:58
  • Supplier:
    Accela ChemBio Inc.
  • Tel:(+1)-858-699-3322
  • Country:United States
  • ProdList:19969
  • Advantage:58
5-Hydroxytryptophan Spectrum
56-69-9, 5-HydroxytryptophanRelated Search:
  • DL-5-HTP
  • 5-Hydroxytryptophan(5-HTP)
  • DL-2-Amino-3-(5-hydroxyindolyl)propionic acid, DL-5-HTP
  • 5-HTP (Griffonia Seeds P.E.)
  • 5-Hydroxy-α-amino-1H-indole-3-propionic acid
  • NSC-92523
  • USAF CB-96
  • 2-azanyl-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
  • 5-HTP AMino acid
  • 5-Hydroxytryptophan (CAS 56-69-9)
  • 5-Hydroxy-DL-tryphophane
  • Tryptophan, 5-hydroxy-
  • 5-Hydroxytryptophan (5-HTP) Synonyms DL-5-Hydroxytryptophan
  • 5-Hydroxytryptophan DL-5-Hydroxytryptophan
  • 5-hydroxy-tryptopha
  • 5-hydroxytryptophane
  • 5-hydroxytrytophan
  • nci-c56644
  • TIMTEC-BB SBB003354
  • 5-HydroxyTryptophane (5-HTP)
  • 5-Hydroxy-L-Tryptophan 5-Hydroxy-Tryptophan
  • 5-Hydroxytryptophan20%50%90%99%
  • 5-Hydroxy-DL-tryptophane
  • H-DL-Trp(5-OH)-OH
  • (114-03-4) 5-hydroxytryptophan
  • 5-Hydroxytryptophan 56-69-9
  • JACS-56-69-9
  • 5-Hydroxy-DL-tryptophan&gt
  • 5-Hydroxytryptophan USP/EP/BP
  • 56-69-9
  • Indoles
  • Tryptophans
  • Inhibitors
  • Plant extracts
  • Herb extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Standard extract