Methiothepin mesylate salt has been used to explore the relationship between circulating cells and the niche. It has also been used in serotonin (5-HT) and antagonists in vivo bioassays and in in vivo antagonist and lipopolysaccharide stimulations.
Methiothepin belongs to a new class of dibenzothiophenes. Methiothepin possesses neuroleptic activity.
Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
5-HT1A Receptor: 7.10 (pKd); 5-HT1B Receptor: 7.28 (pKd); 5-HT1C Receptor: 7.56 (pKd); 5-HT1D Receptor: 6.99 (pKd); 5-HT5A Receptor: 7.0 (pKd); 5-HT5B Receptor: 7.8 (pKd); 5-HT6 Receptor: 8.74 (pKd); 5-HT7 Receptor: 8.99 (pKd); 5-HT2A Receptor: 8.50 (pKi); 5-HT2B Receptor: 8.68 (pKi); 5-HT2C Receptor: 8.35 (pKi)
