Chemical Properties
Crystallized, melting point 126～128°C. Lofexidine Hydrochloride (Lofexidine Hydrochloride): C11H12(Cl2N2OHCl.[21498-08-8]. Crystallized from ethanol-ether or 2-propanol, melting point 221-223°C; also melting point 230-232°C. Very soluble in water or ethanol, slightly soluble in 2-propanol, several insoluble in ether. Acute toxicity LD50 mice, rats and dogs (mg/kg): 74～147 orally; 8～18 intravenously.
Definition
ChEBI: Lofexidine is a member of imidazoles, a dichlorobenzene, an aromatic ether and a carboxamidine. It has a role as an alpha-adrenergic agonist and an antihypertensive agent.
