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Chlorpheniramine maleate

Chlorpheniramine maleate  Structure
Chlorpheniramine maleate
  • CAS No.113-92-8
  • Chemical Name:Chlorpheniramine maleate
  • CBNumber:CB9142008
  • Molecular Formula:C20H23ClN2O4
  • Formula Weight:390.86
  • MOL File:113-92-8.mol
Chlorpheniramine maleate Property
  • Melting point: :130-135 °C (lit.)
  • alpha  :-1~+1°(D/20℃)(c=5,DMF)
  • Density  :1.1984 (rough estimate)
  • refractive index  :1.6800 (estimate)
  • Flash point: :9℃
  • storage temp.  :2-8°C
  • solubility  :Freely soluble in water, soluble in ethanol (96 per cent)
  • form  :neat
  • PH :4.0~5.5 (10g/l, 25℃)
  • Water Solubility  :1-5 g/100 mL at 21 ºC
  • Merck  :14,2180
  • InChIKey :DBAKFASWICGISY-BTJKTKAUSA-N
  • FDA 21 CFR :310.545; 341.12
  • FDA UNII :V1Q0O9OJ9Z
  • EPA Substance Registry System :Chlorpheniramine maleate (113-92-8)
Safety
  • Hazard Codes  :T,F
  • Risk Statements  :25-39/23/24/25-23/24/25-11
  • Safety Statements  :36/37/39-45-36/37-16
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • RTECS  :US6504000
  • TSCA  :Yes
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • HS Code  :29333990
  • Toxicity :LD50 orally in mice: 162 mg/kg (Smith)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H301+H311+H331-H370-H302
  • Precautionary statements P264-P270-P301+P312a-P330-P501a-P301+P312+P330-P210-P260-P280-P301+P310-P311
Chlorpheniramine maleate Price More Price(14)
  • Brand: Sigma-Aldrich
  • Product number: C-036
  • Product name : Chlorpheniramine maleate salt solution
  • Purity: 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
  • Packaging: 036-1ml
  • Price: $20.3
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: C-036
  • Product name : Chlorpheniramine maleate salt solution
  • Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging: 1 mL
  • Price: $20.9
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1123000
  • Product name : Chlorpheniramine maleate
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 125mg
  • Price: $297
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: C0873
  • Product name : Chlorpheniramine Maleate
  • Purity: >99.0%(HPLC)(T)
  • Packaging: 25g
  • Price: $67
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: B25238
  • Product name : Chlorpheniramine maleate, 99%
  • Purity: 
  • Packaging: 5g
  • Price: $38
  • Updated: 2021/03/22
  • Buy: Buy

Chlorpheniramine maleate Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Uses An antagonist of the histamine H1-receptor
  • Uses Antihistaminic
  • brand name Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).
  • General Description Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.
  • General Description Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.
  • Air & Water Reactions Water soluble.
  • Reactivity Profile A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
  • Fire Hazard Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.
  • Safety Profile Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.
  • Veterinary Drugs and Treatments Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.
  • Dosage forms 4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.
Chlorpheniramine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
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