Overview Uses
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ETHYL OLEATE

Overview Uses
ETHYL OLEATE Structure
ETHYL OLEATE
  • CAS No.111-62-6
  • Chemical Name:ETHYL OLEATE
  • CBNumber:CB7301038
  • Molecular Formula:C20H38O2
  • Formula Weight:310.51
  • MOL File:111-62-6.mol
ETHYL OLEATE Property
Safety
  • Safety Statements  :23-24/25-22
  • WGK Germany  :2
  • RTECS  :RG3715000
  • F  :10-23
  • TSCA  :Yes
  • HS Code  :29161900
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
ETHYL OLEATE Price More Price(25)
  • Brand: Sigma-Aldrich
  • Product number: 268011
  • Product name : Ethyl oleate
  • Purity: 98%
  • Packaging: 5g
  • Price: $47.4
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: W245000
  • Product name : Ethyl oleate
  • Purity: natural, ≥85%
  • Packaging: 100 g
  • Price: $73.7
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: W245000
  • Product name : Ethyl oleate
  • Purity: natural, ≥85%
  • Packaging: 500 g
  • Price: $245
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1266609
  • Product name : Ethyl oleate
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 1ml
  • Price: $399
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: W245000
  • Product name : Ethyl oleate
  • Purity: natural, ≥85%
  • Packaging: 1 kg
  • Price: $400
  • Updated: 2021/03/22
  • Buy: Buy

ETHYL OLEATE Chemical Properties,Usage,Production

  • Overview Ethyl oleate is a colourless liquid that is normally formed by condensing ethanol and oleic acid. Notably, the compound is normally produced by the body during intoxication of ethanol. Its other names are 9-Octadecenoic acid (Z)-, Ethyl cis-9-octadecenoate, (Z)-9-Octadecenoic acid ethyl ester, and Oleic acid, ethyl ester. The compound contributed to approximately 17% of the total fatty acids esterified to phosphatidylcholine in porcine platelets. Ethyl oleate is neutral and is a more lipid-soluble form of oleic acid.
    The compound is one of the fatty acid ethyl esters that is generated after the breakdown of ethanol in the body. Moreover, ethyl oleate usually acts as a toxic mediator of ethanol in the heart, liver, pancreas, and brain.
  • Uses Pharmaceutical Industry
    Ethyl oleate is utilized as an ingredient for the preparations of pharmaceutical drugs that involves lipophilic substances such as steroids. Due to its quick degradation of the digestive system, ethyl oleate is employed as a way for intramuscular drug delivery by compounding pharmacies. In some cases, the compound is used in the preparation of day-to-day doses of progesterone in the sustenance of pregnancy.
    Transport Industry
    It is used in the transport industry as a lubricant and as a plasticiser. It is also used as a planting agent and for treating surfaces.
    Food Industry
    Ethyl oleate is used as a food additive and is regulated by the Food and Drug Administration. It is also used as a flavouring agent in food.
  • Description Ethyl oleate is a fatty acid ester formed by the condensation of oleic acid and ethanol. It is a colorless to light yellow liquid. Ethyl oleate is produced by the body during ethanol intoxication.
    Ethyl oleate is used as a solvent for pharmaceutical drug preparations involving lipophilic substances such as steroids. It also finds use as a lubricant and a plasticizer.
    Ethyl oleate is regulated as a food additive by the Food and Drug Administration under "Food Additives Permitted for Direct Addition to Food for Human Consumption", 21CFR172.515.
    Ethyl oleate has been identified as a primer pheromone in honeybees.
    Ethyl oleate is one of the fatty acid ethyl esters (FAEE) that is formed in the body after ingestion of ethanol. There is a growing body of research literature that implicates FAEEs such as ethyl oleate as the toxic mediators of ethanol in the body (pancreas, liver, heart, and brain). Among the speculations is that ethyl oleate may be the toxic mediator of alcohol in fetal alcohol syndrome. The oral ingestion of ethyl oleate has been carefully studied and due to rapid degradation in the digestive tract it appears safe for oral ingestion. Ethyl oleate is not currently approved by the U.S. Food and Drug Administration for any injectable use. However, it is used by compounding pharmacies as a vehicle for intramuscular drug delivery, in some cases to prepare the daily doses of progesterone in support of pregnancy. Studies which document the safe use of ethyl oleate in pregnancy for both the mother and the fetus have never been performed.
  • Chemical Properties Ethyl oleate has a faint, floral note.
  • Chemical Properties clear pale yellow oily liquid
  • Chemical Properties Ethyl oleate occurs as a pale yellow to almost colorless, mobile, oily liquid with a taste resembling that of olive oil and a slight, but not rancid odor.
    Ethyl oleate is described in the USP32–NF27 as consisting of esters of ethyl alcohol and high molecular weight fatty acids, principally oleic acid. A suitable antioxidant may be included.
  • Occurrence Reported found in cocoa, buckwheat, elderberry and babaco fruit (Carica pentagona Heilborn).
  • Uses Ethyl oleate is a flavoring and fragrance agent.
  • Uses It was obtained by the hydrolysis of various animal and vegetable fats and oils.
  • Uses Usually used to prepare the oily phase of self-microemulsifying drug delivery system (SMEDDS) for tacrolimus (Tac).
  • Production Methods Ethyl oleate is prepared by the reaction of ethanol with oleoyl chloride in the presence of a suitable hydrogen chloride acceptor.
  • Definition ChEBI: A long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of oleic acid with the hydroxy group of ethanol.
  • Preparation By direct esterification of oleic acid with ethyl alcohol in the presence of HCl at the boil; in the presence of Twitchell’s reagent or chlorosulfonic acid.
  • Aroma threshold values Detection: 130 to 610 ppm
  • Pharmaceutical Applications Ethyl oleate is primarily used as a vehicle in certain parenteral preparations intended for intramuscular administration. It has also been used as a solvent for drugs formulated as biodegradable capsules for subdermal implantation) and in the preparation of microemulsions containing cyclosporinand norcantharidin.
    Microemulsion formulations containing ethyl oleate have also been proposed for topical and ocular delivery, and for liver targeting following parenteral administration. Ethyl oleate has been used in topical gel formulations, and in self-microemulsifying drug delivery systems for oral administration.
    Ethyl oleate is a suitable solvent for steroids and other lipophilic drugs. Its properties are similar to those of almond oil and peanut oil. However, it has the advantage that it is less viscous than fixed oils and is more rapidly absorbed by body tissues.
    Ethyl oleate has also been evaluated as a vehicle for subcutaneous injection.
  • Safety Ethyl oleate is generally considered to be of low toxicity but ingestion should be avoided. Ethyl oleate has been found to cause minimal tissue irritation. No reports of intramuscular irritation during use have been recorded.
  • Carcinogenicity Not listed by ACGIH, California Proposition 65, IARC, NTP, or OSHA.
  • storage Ethyl oleate should be stored in a cool, dry place in a small, wellfilled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas. Ethyl oleate oxidizes on exposure to air, resulting in an increase in the peroxide value. It remains clear at 5°C, but darkens in color on standing. Antioxidants are frequently used to extend the shelf life of ethyl oleate. Protection from oxidation for over 2 years has been achieved by storage in amber glass bottles with the addition of combinations of propyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, and citric or ascorbic acid. A concentration of 0.03% w/v of a mixture of propyl gallate (37.5%), butylated hydroxytoluene (37.5%), and butylated hydroxyanisole (25%) was found to be the best antioxidant for ethyl oleate.
    Ethyl oleate may be sterilized by heating at 150°C for 1 hour.
  • Incompatibilities Ethyl oleate dissolves certain types of rubber and causes others to swell. It may also react with oxidizing agents.
  • Regulatory Status Included in the FDA Inactive Ingredients Database (transdermal preparation). Included in parenteral (intramuscular injection) and nonparenteral (transdermal patches) medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
ETHYL OLEATE Preparation Products And Raw materials
Raw materials
Preparation Products
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111-62-6, ETHYL OLEATERelated Search:
  • (Z)-9-Octadecenoic acid ethyl ester
  • (Z)-9-Octadecenoicacidethylester
  • 9-Octadecenoicacid(Z)-,ethylester
  • Ethyl oleate (OA-EE)
  • oleic
  • FEMA 2450
  • ETHYL (Z)-9-OCTADECENOATE
  • ETHYL OLEATE
  • DELTA 9 CIS OCTADECENOIC ACID ETHYL ESTER
  • OLEIC ACID ETHYL ESTER
  • ETHYL OLEATE, TECH., 70%
  • ETHYL OLEATE, BP
  • Ethyl oleate, mixture of homologeous fatty acid esters, 98%
  • Ethyl oleate, tech., mixture of isomers, 90%
  • 9-Octadecenoic acid (9Z)-, ethyl ester
  • ethylis oleas
  • ETHYLOLEATE,NF
  • Ethyloleat
  • cis-octadec-9-enoicacidethylester
  • Ethyl (9Z)-9-octadecenoate
  • Ethyl cis-9-octadecenoate
  • Ethyl(Z)-9-octadeceneoate
  • ethylcis-9-octadecenoate
  • ethyloleate,mixtureofisomers
  • octadec-9-enoicacid,ethylester
  • ETHY OLEATE, NATURAL & KOSHER
  • ETHYL OLEATE KOSHER, FOOD GRADE SYNTHETIC
  • ETHYL OLEATE TECH GRADE.
  • Ethylis oleas, Oleic acid ethyl ester
  • Ethyl oleate,90%,tech., mixture of isomers
  • Ethyl oleate, 98%, mixture of homologeous fatty acid esters
  • (9Z)-9-Octadecenoic acid ethyl ester
  • Oleic acid ethyl
  • Ethyl oleate,Oleic acid ethyl ester
  • Ethyl oleate 2g [111-62-6]
  • Ethyl oleate 10g [111-62-6]
  • (9Z)-
  • Ethyl oleate Ph Eur
  • Ethyl oleate technical grade, 70%
  • Ethyl oleate tested according to Ph.Eur.
  • Ethyl oleate, Mixture of hoMologeous fatty acid esters, 98% 250GR
  • Ethyl oleate, technical, 70%
  • Oleic acid ethyl ester≥ 99% (GC)
  • Ethyl Oleate(C18:1)
  • ethyl (Z)-octadec-9-enoate
  • Ethyl oleate, 75.0%(GC)
  • EthylOleate&gt
  • Ethyl oleate@10 mg/mL in Hexane
  • ETHYL OLEATE USP/EP/BP
  • Elhyl oleate
  • Solvent Ethyl Oleate Eo CAS 111-62-6
  • 111-62-6
  • 111-62-2
  • CH3CH27CHCHCH27CO2CH2CH3
  • CH3CH27CHCHCH27COOC2H5
  • Higher Fatty Acids & Higher Alcohols
  • Unsaturated Higher Fatty Acid Esters
  • Fatty Acid Esters (Plasticizer)