Description
This base was first prepared synthetically by Partheil and subsequently discovered
in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora
microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.)
Richards. It is laevorotatory with [α]
20D - 221 ° (H20) and furnishes the following
crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide,
m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p.
206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the
methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.
Chemical Properties
Colourless Needles
Uses
N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.
General Description
N-Methylcytisine is a nicotinic alkaloid found in
Caulophyllum thalictroides, also known as blue cohosh.
Hazard
Extremely toxic; cardiotoxic; poisonous.
Biochem/physiol Actions
N-Methylcytisine is toxic and binds selectively to nicotinic acetylcholine receptors in the CNS.
References
Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)
