Description
Betaxolol hydrochloride is a cardioselective β-adrenergic blocker, reportedly devoid
of intrinsic sympathomimetic and membrane stabilizing properties. Its long
duration of action permits once-daily dosing in mild to moderate hypertension. It
is also being evaluated in glaucoma.
Description
Betaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β
1-adrenergic receptor antagonist. Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .
References
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10.1016/j.jchromb.2005.05.023[2] PANKAJ GUPTA R G. Amino Functionalized Graphene Oxide and Polymer Nanocomposite Based Electrochemical Platform for Sensitive Assay of Anti-Doping Drug Atenolol in Biological Fluids[J]. Journal of The Electrochemical Society, 2016, 163 1. DOI:
10.1149/2.0281613jes[3] A WELLSTEIN G G B D Palm. Affinity and selectivity of beta-adrenoceptor antagonists in vitro.[J]. Journal of Cardiovascular Pharmacology, 1986, 8 Suppl 11: S36-40. DOI:
10.1097/00005344-198511001-00006[4] DOROTA POZAROWSKA Zbigniew D Piotr Pozarowski. Cytometric assessment of cytostatic and cytotoxic effects of topical glaucoma medications on human epithelial corneal line cells[J]. Cytometry Part B: Clinical Cytometry, 2009, 78B 2: 130-137. DOI:
10.1002/cyto.b.20493[5] N. SHARIF. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.[J]. Journal of Ocular Pharmacology and Therapeutics, 2001, 26 1: 305-317. DOI:
10.1089/108076801753162726[6] GLYN CHIDLOW Neville N O José Melena. Betaxolol, a β1-adrenoceptor antagonist, reduces Na+ influx into cortical synaptosomes by direct interaction with Na+ channels: comparison with other β-adrenoceptor antagonists[J]. British Journal of Pharmacology, 2009, 130 4: 759-766. DOI:
10.1038/sj.bjp.0703369
