Chemical Properties
CLEAR YELLOW LIQUID
Chemical Properties
Colorless to yellow liquid; pepper-like aroma.
Uses
Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation1Reactant for synthesis of:• ;Azepan-4-ones via two step [5+2] annulation2• ;2-Aminobenzoxazoles3• ;Unsymmetrically substituted ureas4• ;Corticotropin-releasing factor receptor type 1 antagonists5• ;Gefitinib analogues with anti-tumor activity6
Uses
2-Methylpiperidine, is used for the oxidation of secondary amines to nitrones by means of H2O2 catalyzed by Sodium tungsten oxide dihydrate.
Definition
ChEBI: 2-Methylpiperidine is a member of piperidines.
Aroma threshold values
High strength; ammoniacal type; recommend smelling in a 1.0% solution or less.
Taste threshold values
Amine, creamy, taco, lettuce taste at 5 ppm in water.
Synthesis Reference(s)
Journal of the American Chemical Society, 111, p. 4108, 1989
DOI: 10.1021/ja00193a056
