Chemical Properties
light yellow to brown crystalline low melting mass
Uses
2-Picoline N-oxide is used in proteomics research. Also used as pharmaceutical intermediates.
Definition
ChEBI: Picoline N-oxide is a member of methylpyridines and a member of pyridine N-oxides.
Application
2-Methylpyridine 1-oxide is a useful building block for organic synthesis.
Purification Methods
Purify the N-oxide by fractional distillation, and it can be recrystallised from *C6H6/hexane but is hygroscopic. [Bullitt & Maynard J Am Chem Soc 76 1370 1954, Ross et al. J Am Chem Soc 78 3625 1956, IR: Wiley & SlaymAker J Am Chem Soc 79 2233 1957.] The picrate has m 125-126.5o (from EtOH) [Boekelheide & Linn J Am Chem Soc 76 1286 1954]. The phthalate has m 115-116o (from EtOH) [den Hertog et al. Recl Trav Chim Pays-Bas 70 591 1951.]. [Beilstein 20 III/IV 2689, 20/5 V 479.]
