Chebulic Acid

Description

Chebulic acid is a phenolic compound isolated from the ripe fruits of Terminalia chebula. This compound possesses an isomer, neochebulic acid. Chebulic acid is a component of transformed ellagitannins such as chebulagic acid or chebulinic acid.
Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulmonary vascular dysfunction.

Bioactivities

Chebulinic acid showed many bioactivities including inhibition of cancer cell growth, inhibiting the contractile responses of cardiovascular muscles, anti-fungal, anti-bacterial activities etc. In-vitro anti-cancer activity of Chebulinic acid on Colon adenocarcinoma HT-29 cancer cell lines by using MTT cell growth inhibition assay was stuied. The maximum percentage inhibition of cancer cell lines for Chebulinic acid was found to be 41.2% at a dose of 200µg/ml. Chebulinic acid extraction from Terminalia chebula plays a vital role in medicine, biotechnology and various pharmacological activities.

Uses

Chebulic acid can be used for the polypharmacology of metabolites of medicinal plants to target SARS-CoV-2. It can also be used as a therapeutic agent to prevent insulin sensitivity and oxidative stress induced dysfunction of beta cells for diabetes.

target

VEGFR | ROS