Description
10-Gingerol is a phenol that has been found in
Z. officinale and has diverse biological activities. It scavenges DPPH , superoxide, and hydroxyl radicals in cell-free assays (IC
50s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; ) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM. 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils. It is active against
M. avium and
M. tuberculosis (MICs = 25 and 50 μg/ml, respectively). 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.
Chemical Properties
White waxy, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ginger.
Uses
(+)-(S)-[10]-Gingerol has been observed to exhibit anti-oxidant behaviour towards lipids and is effective in suppressing obesity and adipose tissue inflammation.
Definition
ChEBI: (10)-Gingerol is a beta-hydroxy ketone, a member of phenols and a monomethoxybenzene.
Biochem/physiol Actions
[10]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with anti-inflammatory and antioxidant activity.
in vivo
10-Gingerol (30 mg/kg, i.p., 7 consecutive days) reverses body weight loss, declines disease activity index (DAI), decreasing myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, as well as restoring SOD activity, reduces the serum TNF-α and IL-1β levels, ameliorates mucosa inflammation and/or defect in rats with DSS-induced acute ulcerative colitis[4].
| Animal Model: | Rats with DSS-induced acute ulcerative colitis[4] |
| Dosage: | 30 mg/kg |
| Administration: | i.p., 7 consecutive days |
| Result: | Reversed body weight loss and significantly declined DAI, reduced the serum TNF-α and IL-1β levels, ameliorated mucosa inflammation and/or defect in rats with DSS-induced acute ulcerative colitis in rats with DSS-induced acute ulcerative colitis. |
References
[1] SWARNALATHA DUGASANI . Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol[J]. Journal of ethnopharmacology, 2010, 127 2: Pages 515-520. DOI:
10.1016/j.jep.2009.10.004[2] RAMADAN A ALI. Antineutrophil properties of natural gingerols in models of lupus.[J]. JCI insight, 2021. DOI:
10.1172/jci.insight.138385[3] R. D. HISERODT R. T R S G Franzblau. Isolation of 6-, 8-, and 10-Gingerol from Ginger Rhizome by HPLC and Preliminary Evaluation of Inhibition of Mycobacterium avium and Mycobacterium tuberculosis[J]. Journal of Agricultural and Food Chemistry, 1998, 46 7: 2504-2508. DOI:
10.1021/jf970948l[4] MEGAN M. BERNARD David W H Jason R McConnery. [10]-Gingerol, a major phenolic constituent of ginger root, induces cell cycle arrest and apoptosis in triple-negative breast cancer cells[J]. Experimental and molecular pathology, 2017, 102 2: Pages 370-376. DOI:
10.1016/j.yexmp.2017.03.006
