10-Gingerol is a phenol that has been found in
Z. officinale and has diverse biological activities.
1,2,3,4 It scavenges DPPH (Item No.
14805), superoxide, and hydroxyl radicals in cell-free assays (IC
50s = 10.47, 1.68, and 1.35 μM, respectively) and inhibits oxidative burst induced by N-formyl-Met-Leu-Phe (fMLP; Item No.
21495) in isolated human polymorphonuclear (PMN) neutrophils when used at a concentration of 6 μM.
1 10-Gingerol inhibits NETosis and the production of reactive oxygen species (ROS) induced by LPS or lupus-relevant stimuli, including ribonucleoprotein-containing immune complexes and anti-phospholipid antibodies, in isolated human neutrophils.
2 It is active against
M. avium and
M. tuberculosis (MICs = 25 and 50 μg/ml, respectively).
3 10-Gingerol (200 μM) is also cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells.
4 
