β-Chlorpropiophenon

Bezeichnung:β-Chlorpropiophenon

CAS-Nr936-59-4

Englisch Name:3-Chloropropiophenone

CBNumberCB9332104

SummenformelC9H9ClO

Molgewicht168.62

MOL-Datei936-59-4.mol

Synonyma

β-Chlorpropiophenon

β-Chlorpropiophenon physikalisch-chemischer Eigenschaften

Schmelzpunkt	48-50 °C(lit.)
Siedepunkt	113-115 °C4 mm Hg(lit.)
Dichte	1.1115 (rough estimate)
Brechungsindex	1.5350 (estimate)
Flammpunkt	>230 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Off-White to Pale Yellow
Wasserlöslichkeit	Insoluble
BRN	2043580
Stabilität	Stable. Incompatible with strong bases, strong oxidizing agents.
CAS Datenbank	936-59-4(CAS DataBase Reference)
NIST chemische Informationen	1-Propanone, 3-chloro-1-phenyl-(936-59-4)
EPA chemische Informationen	1-Propanone, 3-chloro-1-phenyl- (936-59-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	37/39-26-24/25
WGK Germany	3
TSCA	Yes
HS Code	29147000

Gefahreninformationscode (GHS)

3-Chloropropiophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.
Chemische Eigenschaften
faintly yellow to tan crystalline powder
Verwenden
3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.
Verwenden
3-Chloropropiophenone is an Impurity of Fluoxetine (F597100).
Synthese
Adding 3' -chlorobenzene acetone and levorotatory prolinol into 95% ethanol and stirring; cooling after the reaction liquid is wholly dissolved; adding potassium borohydride into the reaction solution in batches, and preserving heat after adding; heating the reaction solution for reflux reaction, and concentrating the reaction solution under reduced pressure; adding n-hexane into the reaction solution, heating, and adding active carbon for heat preservation and decoloration; filtering the reaction solution, leaching a filter cake by using normal hexane, and collecting filtrate; crystallizing and filtering the filtrate, leaching the filter cake once with n-hexane, and drying in vacuum to obtain 3-Chloropropiophenone.

3-Chloropropiophenone Upstream-Materialien And Downstream Produkte

β-Chlorpropiophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

936-59-4, 3-Chloropropiophenone Verwandte Suche:

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