3-Chlorpropionylchlorid

Bezeichnung:3-Chlorpropionylchlorid

CAS-Nr625-36-5

Englisch Name:3-Chloropropionyl chloride

CBNumberCB8691211

SummenformelC3H4Cl2O

Molgewicht126.97

MOL-Datei625-36-5.mol

Synonyma

3-Chlorpropionylchlorid

3-Chlorpropionylchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	-32 °C
Siedepunkt	143-145 °C(lit.)
Dichte	1.33 g/mL at 25 °C(lit.)
Dampfdruck	10.0 hPa
Brechungsindex	n20/D 1.457(lit.)
RTECS-Nr.	UC3934000
Flammpunkt	146 °F
storage temp.	Flammables area
Löslichkeit	Chloroform, Ethyl Acetate
Aggregatzustand	liquid
Farbe	red-brown
PH	<7 (H2O)
Explosionsgrenze	8.8-20.2%(V)
Wasserlöslichkeit	reacts
Sensitive	Moisture Sensitive
BRN	635814
Stabilität	Moisture Sensitive
InChIKey	INUNLMUAPJVRME-UHFFFAOYSA-N
CAS Datenbank	625-36-5(CAS DataBase Reference)
NIST chemische Informationen	Propanoyl chloride, 3-chloro-(625-36-5)
EPA chemische Informationen	Propanoyl chloride, 3-chloro- (625-36-5)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	14-22-26-34-35-10
S-Sätze:	23-26-36/37/39-45-38-16-8
RIDADR	UN 3390 6.1/PG 1
WGK Germany	1
F	21
TSCA	Yes
HazardClass	6.1
PackingGroup	I
HS Code	29159080

Gefahreninformationscode (GHS)

3-Chloropropionyl chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R14:Reagiert heftig mit Wasser.
R22:Gesundheitsschädlich beim Verschlucken.
R26:Sehr giftig beim Einatmen.
R34:Verursacht Verätzungen.
R35:Verursacht schwere Verätzungen.
R10:Entzündlich.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S8:Behälter trocken halten.
Beschreibung
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.
Chemische Eigenschaften
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.
Verwenden
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.
synthetische
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
Reaktionen
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist.

(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported.

(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
Flammability and Explosibility
Non flammable
Synthese
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
Synthese
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example, dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.

3-Chloropropionyl chloride Upstream-Materialien And Downstream Produkte

3-Chlorpropionylchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

625-36-5, 3-Chloropropionyl chloride Verwandte Suche:

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