Sulfamerazinnatrium

Bezeichnung:Sulfamerazinnatrium

CAS-Nr127-58-2

Englisch Name:Sulfamerazine sodium

CBNumberCB9289260

SummenformelC11H13N4NaO2S

Molgewicht288.3

MOL-Datei127-58-2.mol

Synonyma

Sulfamerazinnatrium

Sulfamerazinnatrium physikalisch-chemischer Eigenschaften

RTECS-Nr.	WP0760000
storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	Powder
Wasserlöslichkeit	Soluble in DMSO or water
CAS Datenbank	127-58-2(CAS DataBase Reference)
EPA chemische Informationen	Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)-, monosodium salt (127-58-2)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/22-36/38-36/37/38
S-Sätze:	7-24-45-36-26
WGK Germany	3
TSCA	Yes

Gefahreninformationscode (GHS)

Sulfamerazine sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
R36/38:Reizt die Augen und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S7:Behälter dicht geschlossen halten.
S24:Berührung mit der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM. In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice. It also prevents death of Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.
Verwenden
Involved in characterization of chirosan membranes for the transport of drugs1,2,3
Trademarks
Bio hubber simple;Cremo-merazine;Debnal m;Mebacid;Neotrizine;Peccocode;Septosil;Spanbolet ii;Tersulpha;Trisulfaminic;Trisulpha.
Weltgesundheitsorganisation (WHO)
Sulfamerazine sodium, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfamerazine is still used in some countries usually in combination with other sulfonamides.
Sicherheitsprofil
Moderately toxic by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.

Sulfamerazinnatrium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

127-58-2, Sulfamerazine sodium Verwandte Suche:

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