Estradiolbenzoat

Bezeichnung:Estradiolbenzoat

CAS-Nr50-50-0

Englisch Name:Estradiol benzoate

CBNumberCB9131644

SummenformelC25H28O3

Molgewicht376.5

MOL-Datei50-50-0.mol

Synonyma

Estradiolbenzoat

Estradiolbenzoat physikalisch-chemischer Eigenschaften

Schmelzpunkt	191-198 °C(lit.)
alpha	D25 +58 to +63° (c = 2 in dioxane)
Siedepunkt	465.03°C (rough estimate)
Dichte	1.0493 (rough estimate)
Brechungsindex	1.5460 (estimate)
storage temp.	2-8°C
Löslichkeit	Practically insoluble in water, freely soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in methanol.
pka	15.06±0.40(Predicted)
Farbe	White
Wasserlöslichkeit	0.4mg/L(25 ºC)
Merck	3703
BRN	3107526
CAS Datenbank	50-50-0(CAS DataBase Reference)
NIST chemische Informationen	Estradiol benzoate(50-50-0)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60-61-40
S-Sätze:	53-22-36/37/39-45
WGK Germany	3
RTECS-Nr.	KG4050000
F	8
HS Code	29372319

Gefahreninformationscode (GHS)

Estradiol benzoate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R61:Kann das Kind im Mutterleib schädigen.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
White solid
Verwenden
Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the tr eatment of lesions produced by diminution of bodily production of estrogens.
Verwenden
antiacne, antineoplastic
Verwenden
Estradiol is the major estrogen secreted by the premenopausal ovary. Estradiol benzoate is an estradiol analog which contains a benzyl ester at the C-3 position. Estradiol benzoate is useful in the treatment of lesions produced by diminution of bodily production of estrogens.
Definition
ChEBI: A benzoate ester resulting from the formal condensation of benzoic acid with the phenolic hydroxy group of 17beta-estradiol.
Clinical Use
Estradiol is a semisynthetic estrogen compound. Its effects will mimic that of estrogen in animals. The most common use in small animals has been to terminate pregnancy.
Estradiol benzoate also has been used to terminate pregnancy (5-10 mg/kg divided into two or three SQ injections). Estradiol cypionate formulation had high efficacy (95%), but it had serious adverse effects and is not recommended. Estradiol cypionate is longer acting and more potent than other estrogen formulations. Estradiol valerate injection (20 mg/mL) is also available for human medicine to treat hypoestrogenism.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human reproductive effects by intramuscular route: menstrual cycle changes and disorders. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes. See also ESTRADIOL.

Estradiol benzoate Upstream-Materialien And Downstream Produkte

Estradiolbenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50-50-0, Estradiol benzoate Verwandte Suche:

Send Inquriy