Estra-1,3,5(10)-trien-3,17α-diol

Bezeichnung:Estra-1,3,5(10)-trien-3,17α-diol

CAS-Nr57-91-0

Englisch Name:Estradiol

CBNumberCB7289534

SummenformelC18H24O2

Molgewicht272.39

MOL-Datei57-91-0.mol

Synonyma

Estra-1,3,5(10)-trien-3,17α-diol

Estra-1,3,5(10)-trien-3,17α-diol physikalisch-chemischer Eigenschaften

Schmelzpunkt	176-180 °C(lit.)
Siedepunkt	355.44°C (rough estimate)
alpha	D20 +53 to +56° (c = 0.9 in dioxane)
Dichte	1.0708 (rough estimate)
Brechungsindex	1.4800 (estimate)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	ethanol: 50 mg/mL, clear, colorless
Aggregatzustand	powder
pka	10.27±0.60(Predicted)
Farbe	white with slight yellow
Wasserlöslichkeit	3.9mg/L(25 ºC)
Merck	14,3704
CAS Datenbank	57-91-0(CAS DataBase Reference)
NIST chemische Informationen	Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
EPA chemische Informationen	Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

Sicherheit

Kennzeichnung gefährlicher	T,Xn
R-Sätze:	45-48-40
S-Sätze:	53-45-24/25-22
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	KG3750000
F	8-10
HS Code	29372390

Gefahreninformationscode (GHS)

Estradiol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R45:Kann Krebs erzeugen.
R48:Gefahr ernster Gesundheitsschäden bei längerer Exposition.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.
Chemische Eigenschaften
White Solid
Verwenden
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
Definition
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).
Biologische Aktivität
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).
Biochem/physiol Actions
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.
target
Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor
Lager
Room temperature
läuterung methode
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.

Estradiol Upstream-Materialien And Downstream Produkte

Estra-1,3,5(10)-trien-3,17α-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57-91-0, Estradiol Verwandte Suche:

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