Benzoesure Produkt Beschreibung

Benzoic acid Struktur
65-85-0
  • CAS-Nr.65-85-0
  • Bezeichnung:Benzoesure
  • Englisch Name:Benzoic acid
  • Synonyma:Benzoesure;Benzolcarbonsäure<BR>Phenylcarbonsäure
    ha1;e210;210;KRT31;and he;KRTHA1;PUROX B;NA-9094;NSC 149;ai3-0310
  • CBNumber:CB8698780
  • Summenformel:C7H6O2
  • Molgewicht:122.12
  • MOL-Datei:65-85-0.mol
Benzoesure physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :121-125 °C(lit.)
  • Siedepunkt: :249 °C(lit.)
  • Dichte :1.08
  • Dampfdichte :4.21 (vs air)
  • Dampfdruck :10 mm Hg ( 132 °C)
  • Brechungsindex :1.504
  • FEMA  :2131 | BENZOIC ACID
  • Flammpunkt: :250 °F
  • storage temp.  :Store at RT.
  • Löslichkeit : soluble, clear, colorless (95% ethanol, 1gm/3mL)
  • pka :4.19(at 25℃)
  • Aggregatzustand :Solid
  • Farbe :White to yellow-beige to orange
  • PH :2.5-3.5 (H2O, 20℃)(saturated solution)
  • Wasserlöslichkeit :Slightly soluble. 0.34 g/100 mL
  • Merck  :14,1091
  • JECFA Number :850
  • BRN  :636131
  • Stabilität: :Stable. Combustible. Incompatible with strong bases, strong oxidizing agents, alkalies.
  • InChIKey :WPYMKLBDIGXBTP-UHFFFAOYSA-N
  • CAS Datenbank :65-85-0(CAS DataBase Reference)
  • NIST chemische Informationen :Benzoic acid(65-85-0)
  • EPA chemische Informationen :Benzoic acid(65-85-0)
Sicherheit

Benzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

  • Beschreibung Benzoic acid is a colorless, crystalline solid also known as benzenecarboxylic acid. It is the simplest aromatic carboxylic acid, with a carboxyl group (-COOH) bonded directly to the benzene ring. It is found naturally in the benzoin resin of a number of plants.
  • Chemische Eigenschaften Benzoic acid,C6H5COOH, also known as benzene carboxylic acid and phenyl formic acid,is a colorless, monoclinic crystalline solid that has a melting point of 122.4"C and sublimes readily at 100·C. It is an aromatic carboxylic acid that is slightly soluble in water and moderately soluble in alcohol and ether. It is used as a preservative and its derivatives are valuable in medicine, commerce, and industry.
  • Chemische Eigenschaften Benzoic acid is a white crystalline or flaky solid with a faint, pleasant odor.
  • Chemische Eigenschaften Benzoic acid occurs as feathery, light, white or colorless crystals or powder. It is essentially tasteless and odorless or with a slight characteristic odor suggestive of benzoin.
  • History Benzoic acid was first isolated from the dry distillation of benzoin by Blaise de Vigenère (1523–1596) in the 16th century. Friedrich W?hler (1800–1882) and Justus von Liebig (1803–1873) prepared benzoic acid from oxidizing bitter almond oil (benzaldehyde) in 1832 and determined the formula for each of these compounds. They proposed that bitter almond oil, C7H6O, and benzoic acid were derivatives from the benzoyl radical, C7H5O; the radical theory was a major early theory in the development of organic chemistry.
  • Verwenden Sodium benzoate is an important benzoic acid derivative produced industrially by neutralization of benzoic acid using sodium hydroxide or sodium bicarbonate solution. Calcium benzoate, potassium benzoate, and other benzoate salts are also produced. Benzoic acid and sodium benzoate (C6H5COONa) are used as food preservatives and added to foods, juices, and beverages that are acidic.
  • Verwenden benzoic acid is a preservative primarily for use against molds and yeasts. Its performance is classified only as fair against bacteria. Benzoic acid is used in concentrations of 0.05 to 0.1 percent. Although it has a low sensitizing rate, it may cause an allergic reaction in persons sensitive to similar chemicals.
  • Verwenden Benzoic Acid is a preservative that occurs naturally in some foods such as cranberries, prunes, and cinnamon. it is most often used in the form of sodium benzoate because of the low aqueous solubility of the free acid. sodium benzoate is 180 times as soluble in water at 25°c as benzoic acid. the salt in solution is converted to the acid which is the active form. the optimum ph range for microbial inhi- bition is ph 2.5–4.0. it is used in acid foods such as carbonated bev- erages, fruit juices, and pickles. it is also termed benzoate of soda.
  • Verwenden keratolytic
  • Definition ChEBI: A compound comprising a benzene ring core carrying a carboxylic acid substituent.
  • Vorbereitung Methode Although benzoic acid occurs naturally, it is produced commercially by several synthetic methods. One process involves the continuous liquid-phase oxidation of toluene in the presence of a cobalt catalyst at 150–2008℃ and 0.5–5.0 MPa (5.0–50.0 atm) pressure to give a yield of approximately 90% benzoic acid.
    Benzoic acid can also be produced commercially from benzotrichloride or phthalic anhydride. Benzotrichloride, produced by chlorination of toluene, is reacted with 1 mole of benzoic acid to yield 2 moles of benzoyl chloride. The benzoyl chloride is then converted to 2 moles of benzoic acid by hydrolysis. Yield is 75–80%.
    In another commercial process, phthalic anhydride is converted to benzoic acid, in about an 85% yield, by hydrolysis in the presence of heat and chromium and disodium phthalates.
    Crude benzoic acid is purified by sublimation or recrystallization.
  • Vorbereitung Methode Benzoic acid can be synthesized using a number of processes. The industrial method is by the partial oxidation of toluene (C6H5CH3) in liquid phase using manganese, cobalt, vanadium-titanium, or other catalysts. The reaction is carried out at temperatures between 150°C and 200°C. It can also be prepared by the oxidation of benzaldehyde, benzyl alcohol (C6H5CH2OH), and cinnamic acid (C6H5CHCHO2) or by the oxidation of benzene with concentrated sulfuric acid. The hydrolysis of benzonitrile (C6H5CN) produces benzoic acid. It is also produced by the carboxylation of a Grignard reagent followed by acidification; typically carbonation occurs by pouring a Grignard ether over dry ice.
  • Biotechnologische Produktion Benzoic acid is exclusively chemically synthesized on an industrial scale. Toluene from petrochemical routes is oxidized in the presence of the catalyst potassium permanganate to benzoic acid . However, a recent study described for the first time a benzoic acid production process by fermentation using Streptomyces maritimus. The production of benzoic acid during cultivation on glucose, starch, and cellobiose has been investigated. The best results have been achieved with product concentrations of 460 mg.L-1 in 6 days using starch as substrate. Additionally, a genetically modified S. maritimus optimized for endo-glucanasesecretion has been tested on phosphoric acid swollen cellulose. A final product concentration of 125 mg.L-1 was observed after 4 days of cultivation.
  • ERSCHEINUNGSBILD WEISSE KRISTALLE ODER PULVER.
  • PHYSIKALISCHE GEFAHREN Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.
  • CHEMISCHE GEFAHREN Schwache Säure in wässriger Lösung. Reagiert mit Oxidationsmitteln.
  • ARBEITSPLATZGRENZWERTE TLV nicht festgelegt (ACGIH 2005).
    MAK: IIb (nicht festgelegt, aber Informationen vorhanden); (DFG 2005).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation und durch Verschlucken.
  • INHALATIONSGEFAHREN Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz reizt die Augen, die Haut und die Atmungsorgane. Die Substanz kann bei Kontakt einen nicht-allergischen Hautausschlag verursachen.
  • LECKAGE Verschüttetes Material in Kunstsstoffbehältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Gesichtsschutz benutzen. Persönliche Schutzausrüstung: Schutzkleidung. Reste mit viel Wasser wegspülen.
  • Allgemeine Beschreibung Boric acid,H3B03, also known as boracic acid, orthoboric acid, and sassolite, is a white solid composed of triclinic crystals.It is a derivative of barium oxide and is soluble in water. A white crystalline solid. Slightly soluble in water. The primary hazard is the potential for environmental damage if released. Immediate steps should be taken to limit spread to the environment. Used to make other chemicals, as a food preservative, and for other uses.
  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36:Reizt die Augen.
    R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R40:Verdacht auf krebserzeugende Wirkung.
    R63:Kann das Kind im Mutterleib möglicherweise schädigen.
    R43:Sensibilisierung durch Hautkontakt möglich.
    R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
    R45:Kann Krebs erzeugen.
    R41:Gefahr ernster Augenschäden.
    R37/38:Reizt die Atmungsorgane und die Haut.
    R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
  • Air & Water Reaktionen Vapor from molten Benzoic acid may form explosive mixture with air. The finely powdered dry acid is a significant dust explosion hazard [Bretherick, 5th ed., 1995, p. 884]. In air very rapid combustion occurs [Wilson, L.Y. et al., J. Chem. Ed., 1985, 62(10), p. 902]. Slightly soluble in water.
  • Reaktivität anzeigen At high temperature Benzoic acid can react with oxidizing reagents.
  • S-Sätze Betriebsanweisung: S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
    S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
    S24:Berührung mit der Haut vermeiden.
    S22:Staub nicht einatmen.
    S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
    S24/25:Berührung mit den Augen und der Haut vermeiden.
    S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
    S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Hazard Moderately toxic by ingestion. Use restricted to 0.1% in foods.
  • Health Hazard Dust may be irritating to nose and eyes. At elevated temperatures, fumes may cause irritation of eyes, respiratory system, and skin.
  • Brandgefahr Behavior in Fire: Vapor from molten Benzoic acid may form explosive mixture with air. Concentrated dust may form explosive mixture.
  • Aussehen Eigenschaften C7H6O2. Farbloses, geruchloses Pulver oder Plättchen.
  • Pharmazeutische Anwendungen Benzoic acid is widely used in cosmetics, foods, and pharmaceuticals, as an antimicrobial preservative. Greatest activity is seen at pH values between 2.5–4.5.
    Benzoic acid also has a long history of use as an antifungal agent in topical therapeutic preparations such as Whitfield’s ointment (benzoic acid 6% and salicylic acid 3%).
  • Landwirtschaftliche Anwendung Fungicide, Insecticide: Used in the manufacture of benzoates; plasticizers, benzoyl chloride, alkyd resins, in the manufacture of food preservatives, in use as a dye binder in calico printing; in curing of tobacco, flavors, perfumes, dentifrices, standard in analytical chemistry. Not currently registered for use in the U.S. Benzoic acid is currently used in about a dozen European countries.
  • Gefahren für Mensch und Umwelt Gesundheitsschädlich beim Verschlucken. Reizt die Augen. Führt zu Magen-Darm-Störungen.
    Nicht mit Fluor oder Sauerstoff in Berührung bringen.
    LDLo (oral, Mensch): 500 mg/kg.
  • Handelsname RETARDER BA®; MICROL® Preservative; TENN-PLAS®; RETARDEX®; SALVO LIQUID®; SALVO POWDER®; TULSA®
  • Schutzmaßnahmen und Verhaltensregeln Geeignete Schutzhandschuhe als kurzzeitiger Staubschutz.
  • Verhalten im Gefahrfall Trocken aufnehmen. Der Entsorgung zuführen. Nachreinigen.
    Kohlendioxid, Wasser, Pulver.
    Brennbar. Im Brandfall Entstehung gefährlicher Dämpfe möglich.
  • Erste Hilfe Nach Hautkontakt: Mit reichlich Wasser abwaschen.
    Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
    Nach Einatmen: Frischluft.
    Nach Verschlucken: Reichlich Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
    Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
    Ersthelfer: siehe gesonderten Anschlag

  • Sachgerechte Entsorgung Als feste Laborchemikalienabfälle.
  • Toxikologie Four-generation reproductive and developmental toxicities of benzoic acid were examined using diets containing 0, 0.5, and 1% of benzoic acid fed to male and female rats housed together for eight weeks. The second generation was observed through its entire life cycle and the third and fourth generations were examined by autopsy. No changes in normal patterns of growth, reproduction, or lactation during life were recorded and no morphological abnormalities were observed from the autopsies.
    Degradation pathways for benzoic acid also have been studied in detail and the results have supported the harmlessness of this substance. The total dose of benzoic acid is excreted within 10 to 14 hours and 75 to 80% is excreted within 6 hours. After conjugation with glycine, 90% of benzoic acid appears in the urine as hippuric acid. The rest forms a glucuronide,1-benzoylglucuronic acid. The lower aliphatic esters of benzoic acid are first hydrolyzed by esterase, which abounds in the intestinal wall and liver. The resulting benzoic acid subsequently is degraded in the usual manner.
  • Sicherheit(Safety) Ingested benzoic acid is conjugated with glycine in the liver to yield hippuric acid, which is then excreted in the urine; care should be taken when administering benzoic acid to patients with chronic liver disease. Benzoic acid is a gastric irritant, and a mild irritant to the skin. It is also a mild irritant to the eyes and mucous membranes. Allergic reactions to benzoic acid have been reported, although a controlled study indicated that the incidence of urticaria in patients given benzoic acid is no greater than in those given a lactose placebo. It has been reported that asthmatics may become adversely affected by benzoic acid contained in some antiasthma drugs.
    The WHO acceptable daily intake of benzoic acid and other benzoates, calculated as benzoic acid, has been set at up to 5 mg/kg body-weight. The minimum lethal human oral dose of benzoic acid is 500 mg/kg body-weight.
    LD50 (cat, oral): 2 g/kg
    LD50 (dog, oral): 2 g/kg
    LD50 (mouse, IP): 1.46 g/kg
    LD50 (mouse, oral): 1.94 g/kg
    LD50 (rat, oral): 1.7 g/kg
  • mögliche Exposition Benzoic acid is used in production of plasticizers, benzoyl chloride, sodium benzoate and alkyl resins; in the manufacture of benzoates; in the manufacture of food preservatives; as a dye binder in calico printing; in curing of tobacco, flavors, perfumes, dentifrices; standard in analytical chemistry; antifungal agent.
  • Erste Hilfe If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
  • Lager Aqueous solutions of benzoic acid may be sterilized by autoclaving or by filtration.
    A 0.1% w/v aqueous solution of benzoic acid has been reported to be stable for at least 8 weeks when stored in polyvinyl chloride bottles, at room temperature.
    When added to a suspension, benzoic acid dissociates, with the benzoate anion adsorbing onto the suspended drug particles. This adsorption alters the charge at the surface of the particles, which may in turn affect the physical stability of the suspension. The addition of sodium azide has been shown to increase the stability of benzoic acid in skin permeation experiments.
    The bulk material should be stored in a well-closed container in a cool, dry place.
  • Versand/Shipping UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9—Miscellaneous hazardous material, Technical Name Required.
  • läuterung methode For use as a volumetric standard, analytical reagent grade benzoic acid should be carefully fused to ca 130o (to dry it) in a platinum crucible, and then powdered in an agate mortar. Benzoic acid has been crystallised from boiling water (charcoal), aqueous acetic acid, glacial acetic acid, *C6H6, aqueous EtOH, pet ether (b 60-80o), and from EtOH solution by adding water. It is readily purified by fractional crystallisation from its melt and by sublimation in a vacuum at 80o. The S-benzylisothiuronium salt has m 167o (from EtOH/H2O). [Beilstein 9 IV 273.]
  • Inkompatibilitäten Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, caustics, ammonia, amines, isocyanates. Dust forms an explosive mixture with air.
  • Inkompatibilitäten Undergoes typical reactions of an organic acid, e.g. with alkalis or heavy metals. Preservative activity may be reduced by interaction with kaolin.
  • Waste disposal Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
  • Regulatory Status GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, irrigation solutions, oral solutions, suspensions, syrups and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Benzoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
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Benzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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65-85-0, Benzoic acid Verwandte Suche:
  • uniseptbza
  • FEMA 2131
  • CARBOXYBENZENE
  • DRACYLIC ACID
  • BENZENE CARBOXYLIC ACID
  • Benzenemethonic acid
  • benzeneformic acid
  • 'LGC' (2405)
  • 'LGC' (2606)
  • 'LGC' (4003)
  • METTLER TOLEDO CALIBRATION SUBSTANCE ME 18555
  • AKOS BBS-00003711
  • ACIDUM BENZOICUM
  • VEVOVITALL(R)
  • RARECHEM AL BO 0012
  • PUROX B
  • oracylic acid
  • PHENYLFORMIC ACID
  • phenyl carboxylic acid
  • BenzoicAcidGr
  • BENZOIC ACID, REAG.
  • BENZOIC ACID, PHARMA
  • Benzoic acid, for analysis ACS, 99.6%
  • Benzoic acid, for analysis, 99.5%
  • BENZOIC ACID PRIMARY STANDARD
  • BENZOIC ACID REAGENT (ACS)
  • benzoic acid solution
  • mettler toledotm calibration substance me 18555,benzoic acid
  • BENZOICACID,CRYSTAL,REAGENT,ACS
  • BENZOICACID,CRYSTAL,USP,EP,BP,JP
  • BENZOICACID,REAGENTSPECIAL,ACS
  • Benzoic acid 99.5+%
  • BENZOIC ACID (RG)
  • benzenecarbonic acid
  • benzenemonocarbonic acid
  • benzenemonocarboxylic acid
  • BENZOICACIDANDITSCOMMONSALTS
  • BENZOESAEURE TECHNISCH
  • Benzoesure
  • Benzoic acid, ACS, 99.5% min
  • Benzoic Acid Zone Refined (number of passes:20)
  • BENZOIC ACID CRYSTAL
  • Benzoic acid, 99+% , typically 99.6%
  • BENZOIC ACID extrapure AR
  • Benzoic Acid, Crystal, Reagent
  • acidebenzoique
  • Benzoic acid, 99%, extra pure
  • Benzoic acid, 99.5%, for analysis
  • Benzoic acid, 99.6%, for analysis ACS
  • Benzoic acid, for analysis
  • Benzoic acid, for analysis ACS
  • NA-9094
  • BENZOIC ACID
  • Benzoic Acid, Acs Min
  • Benzoic Acid Zone Refined
  • Benzoic acid in Petroleum ether
  • Benzoic acid ,99%
  • Benzoic acid, synthesis grade