Butyl-4-hydroxybenzoat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H318：Verursacht schwere Augenschäden.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Butylparaben Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Beschreibung

  Butylparaben is an antimicrobial agent used in pharmaceutical suspensions. It is act by inhibiting DNA, RNA, and enzymes (eg, ATPase and phosphotransferase) synthesis. Butylparaben may be used alone or with other parabens, chiefly methylparaben and/or propylparaben, in medications. It is common in many liquid and solid (gel cap) OTC products such as Tylenol, Drixoral, Maalox, and Mylanta. Unfortunately, butylparaben concentrations were seldom identified for OTC or prescription products. No attempt was made to identify butylparaben-containing dietary supplements.

• Chemische Eigenschaften

  Butylparaben occurs as colorless crystals or a white, crystalline, odorless or almost odorless, tasteless powder.

• Verwenden

  preservative in many creams, lotions, ointments and other cosmetics, foods (salad dressings, mayonnaise, spiced sauces, mustard, frozen dairy products, baked products), pharmaceutical preparations and dentifrices. It is active against molds, fungi and yeasts, but less active against bacteria. ICU.

• Definition

  ChEBI: Butylparaben is an organic molecular entity. It is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity.

• synthetische

  Butyl paraben is prepared by esterifying p-hydroxybenzoic acid with butyl alcohol in the presence of an acid catalyst, such as sulfuric acid, and an excess of the specific alcohol.

• Vorbereitung Methode

  Butylparaben is prepared by esterification of p-hydroxybenzoic acid with n-butanol.

• Allgemeine Beschreibung

  Odorless white crystals or crystalline powder. Tasteless, but numbs the tongue. Aqueous solutions slightly acidic to litmus.

• Air & Water Reaktionen

  Insoluble in water.

• Reaktivität anzeigen

  Butylparaben is incompatible with strong oxidizing agents and strong caustics.

• Brandgefahr

  Flash point data for Butylparaben are not available; however, Butylparaben is probably combustible.

• Pharmazeutische Anwendungen

  Butylparaben is widely used as an antimicrobial preservative in cosmetics and pharmaceutical formulations.
  It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics, it is the fourth most frequently used preservative.
  As a group, the parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds.
  Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used in formulations. However, this may raise the pH of poorly buffered formulations. See Methylparaben for further information.

• Kontakt-Allergie

  This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

• Sicherheit(Safety)

  Butylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations.
  Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions generally appearing as contact dematitis. Immediate reactions with urticaria and bronchospasm have occurred rarely. See Methylparaben for further information.
  LD₅₀ (mouse, IP): 0.23 g/kg
  LD₅₀ (mouse, oral): 13.2 g/kg

• Lager

  Aqueous butylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature).

• Inkompatibilitäten

  The antimicrobial activity of butylparaben is considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of butylparaben by plastics has not been reported but appears probable given the behavior of other parabens. Some pigments, e.g. ultramarine blue and yellow iron oxide, absorb butylparaben and thus reduce its preservative properties.
  Butylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.

• Regulatory Status

  Butylparaben is regulated by the U.S. Environmental Protection Agency (EPA) under the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). In 1998 its pesticide registration status was listed as "cancelled" (U.S. EPA, 2003).
  Included in the FDA Inactive Ingredients Database (injections; oral capsules, solutions, suspensions, syrups and tablets; rectal, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Butylparaben Upstream-Materialien And Downstream Produkte

Butyl-4-hydroxybenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(671)Suppliers

94-26-8, Butylparaben Verwandte Suche: