Benzylbenzoat Produkt Beschreibung

Benzyl benzoate Struktur
120-51-4
  • CAS-Nr.120-51-4
  • Bezeichnung:Benzylbenzoat
  • Englisch Name:Benzyl benzoate
  • Synonyma:Benzylbenzoat;Benzoesäurephenylmethylester<BR>Benzylbenzolcarboxylat<BR>Benzoesäurebenzylester
    Zylate;ASCABIN;Scabide;Benylate;ASCABIOL;Colebenz;Scabagen;Scabanca;Scabitox;Scobenol
  • CBNumber:CB9152283
  • Summenformel:C14H12O2
  • Molgewicht:212.24
  • MOL-Datei:120-51-4.mol
Benzylbenzoat physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :18 °C
  • Siedepunkt: :323-324 °C(lit.)
  • Dichte :1.118 g/mL at 20 °C(lit.)
  • Dampfdruck :1 mm Hg ( 125 °C)
  • Brechungsindex :n20/D 1.568(lit.)
  • FEMA  :2138 | BENZYL BENZOATE
  • FEMA  :2797 | OCTANAL
  • Flammpunkt: :298 °F
  • storage temp.  :2-8°C
  • Löslichkeit :Miscible with ethanol, alcohol, chloroform, ether, oils.
  • Aggregatzustand :Liquid
  • Farbe :Clear colorless
  • Wasserlöslichkeit :practically insoluble
  • Merck  :14,1127
  • JECFA Number :24
  • BRN  :2049280
  • Stabilität: :Stable. Substances to be avoided include strong oxidizing agents. Combustible.
  • InChIKey :SESFRYSPDFLNCH-UHFFFAOYSA-N
  • CAS Datenbank :120-51-4(CAS DataBase Reference)
  • NIST chemische Informationen :Benzyl Benzoate(120-51-4)
  • EPA chemische Informationen :Benzoic acid, phenylmethyl ester(120-51-4)
Sicherheit
  • Kennzeichnung gefährlicher :Xn,N
  • R-Sätze: :22-51/53
  • S-Sätze: :25-61-46
  • RIDADR  :UN 3082 9 / PGIII
  • WGK Germany  :2
  • RTECS-Nr. :DG4200000
  • Selbstentzündungstemperatur :896 °F
  • TSCA  :Yes
  • HazardClass  :9
  • HS Code  :29163100
  • Giftige Stoffe Daten :120-51-4(Hazardous Substances Data)
  • Toxizität :LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)

Benzyl benzoate Chemische Eigenschaften,Einsatz,Produktion Methoden

  • ERSCHEINUNGSBILD FARBLOSE FLüSSIGKEIT ODER WEISSER FESTSTOFF MIT CHARAKTERISTISCHEM GERUCH.
  • PHYSIKALISCHE GEFAHREN Die Dämpfe sind schwerer als Luft.
  • CHEMISCHE GEFAHREN Beim Verbrennen Bildung giftiger und reizender Rauche.
  • ARBEITSPLATZGRENZWERTE TLV nicht festgelegt (ACGIH 2005).
    MAK nicht festgelegt (DFG 2005).
  • AUFNAHMEWEGE Aufnahme in den Körper durch Inhalation des Aerosols, über die Haut und durch Verschlucken.
  • INHALATIONSGEFAHREN Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
  • WIRKUNGEN BEI KURZZEITEXPOSITION WIRKUNGEN BEI KURZZEITEXPOSITION:
    Die Substanz reizt die Augen, die Haut und die Atemwege.
  • WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen.
  • LECKAGE Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P1-Filter für inerte Partikel.
  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
  • S-Sätze Betriebsanweisung: S25:Berührung mit den Augen vermeiden.
  • Beschreibung Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.
  • Chemische Eigenschaften Benzyl benzoate is a clear, colorless, oily liquid with a slightly aromatic odor. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃ it exists as clear, colorless crystals.
  • Chemische Eigenschaften Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor. It is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.
  • Chemische Eigenschaften Colourless oily liquid with pleasant aromatic odour
  • Verwenden antiarteriosclerotic, hypolipaemic, hepatoprotectant
  • Verwenden Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions.
  • Verwenden Used to kill lice and the mites responsible for the skin condition scabies.
  • Verwenden As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.
  • Verwenden benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
  • Verwenden Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies , for example as a combination drug of benzyl benzoate/disulfiram.
    It has other uses :
    a fixative in fragrances to improve the stability and other characteristics of the main ingredients
    a food additive in artificial flavors
    a plasticizer in cellulose and other polymers
    a solvent for various chemical reactions
    a treatment for sweet itch in horses
    a treatment for scaly leg mites in chickens.
  • Vorbereitung Methode Benzyl benzoate is a constituent of Peru balsam and occurs naturally in certain plant species. Commercially, benzyl benzoate is produced synthetically by the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by the reaction of sodium benzylate with benzaldehyde.
  • Trademarks Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop).
  • Hazard Irritant to eyes, skin.
  • Pharmazeutische Anwendungen Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
    However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
    Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.
  • Kontakt-Allergie Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.
  • Clinical Use Benzyl benzoate is a naturally occurring ester obtained fromPeru balsam and other resins. It is also prepared syntheticallyfrom benzyl alcohol and benzoyl chloride. The ester isa clear colorless liquid with a faint aromatic odor. It is insolublein water but soluble in organic solvents.
    Benzyl benzoate is an effective scabicide when appliedtopically. Immediate relief from itching probably resultsfrom a local anesthetic effect; however, a complete cureis frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized withtriethanolamine. This preparation has the additionaladvantage of being essentially odorless, nonstaining, andnonirritating to the skin. It is applied topically as a lotionover the entire dampened body, except the face.
  • Sicherheit(Safety) Benzyl benzoate is metabolized by rapid hydrolysis to benzoic acid and benzyl alcohol. Benzyl alcohol is then further metabolized to hippuric acid, which is excreted in the urine.
    Benzyl benzoate is widely used as a 25% v/v topical application in the treatment of scabies and as an excipient in intramuscular injections and oral products. Adverse reactions to benzyl benzoate include skin irritation and hypersensitivity reactions. Oral ingestion may cause harmful stimulation of the CNS and convulsions. Benzyl benzoate should be avoided by perople with perfume allergy.
    LD50 (cat, oral): 2.24 g/kg
    LD50 (dog, oral): 22.44 g/kg
    LD50 (guinea pig, oral): 1.0 g/kg
    LD50 (mouse, oral): 1.4 g/kg
    LD50 (rabbit, oral): 1.68 g/kg
    LD50 (rabbit, skin): 4.0 g/kg
    LD50 (rat, oral): 0.5 g/kg
    LD50 (rat, skin): 4.0 g/kg
  • Chemical Synthesis This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.
  • Lager Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided.
  • Inkompatibilitäten Benzyl benzoate is incompatible with alkalis and oxidizing agents.
  • Regulatory Status Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Benzyl benzoate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Benzylbenzoat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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120-51-4, Benzyl benzoate Verwandte Suche:
  • Benzyl benzoate ReagentPlus(R), >=99.0%
  • Benzyl benzoate Vetec(TM) reagent grade, 98%
  • Benzoic acid benzyl ester≥ 99% (GC)
  • VANZOATE(R)
  • VENZONATE(R)
  • Benylate
  • Benzyl alcohol benzoic ester
  • Benzyl ester
  • benzylalcoholbenzoicester
  • Benzylester kyseliny benzoove
  • ASCABIN
  • ASCABIOL
  • ASCABIOL(R)
  • BENZOATO DE BENCILO
  • Benzyl benzoate 99+ %
  • Phenylmethyl benzoate
  • BENZYL BENZOATE, 1GM, NEAT
  • BENZYL BENZOATE 99+% FCC
  • BENZYL BENZOATE 99+% NATURAL FCC
  • BENZYL BENZOATE, USP
  • BENZYL BENZOATE, PH EUR
  • Benzyl Benzoate PQ
  • BENZYL BENZOATE, PHARMA
  • benzylbenzoate,phenylmethylbenzoate
  • Benzylbenzoat
  • Benzyl Benoate
  • Benryl benzoate
  • spasmodin
  • Benzile benzoate
  • BENZYL BENZOATE, NATURAL
  • Benzyl benzoate, EP, BP, USP
  • Benzoic acid benzyl ester, Benzylis benzoas
  • benzyl benzonate
  • benzylesterkyselinybenzoove
  • Benzylets
  • Colebenz
  • femanumber2138
  • Novoscabin
  • Peruscabin
  • Phenylmethyl (benzyl) ester
  • Scabagen
  • Scabanca
  • Scabide
  • Scabiozon
  • Scabitox
  • Scobenol
  • Vanzoate
  • Venzoate
  • Venzonate
  • FEMA 2138
  • BENZOIC ACID BENZYL ESTER
  • BENZOIC ACID PHENYLMETHYL ESTER
  • BENZYL BENZENECARBOXYLATE
  • BENZYL BENZOATE
  • BENZYL PHENYL FORMATE
  • BENZYLIS BENZOAS
  • BENYLATE(R)
  • Benzoic acid benzyl