O-Desmethylvenlafaxine

Bezeichnung:O-Desmethylvenlafaxine

CAS-Nr93413-62-8

Englisch Name:O-Desmethylvenlafaxine

CBNumberCB8496834

SummenformelC16H25NO2

Molgewicht263.38

MOL-Datei93413-62-8.mol

O-Desmethylvenlafaxine physikalisch-chemischer Eigenschaften

Schmelzpunkt	208-213°C
Siedepunkt	403.8±25.0 °C(Predicted)
Dichte	1.115±0.06 g/cm3(Predicted)
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	insoluble in EtOH; ≥13.2 mg/mL in DMSO; ≥2.45 mg/mL in EtOH
Aggregatzustand	Solid
pka	10.04±0.26(Predicted)
Farbe	White to off-white
InChIKey	KYYIDSXMWOZKMP-UHFFFAOYSA-N
LogP	0.33 at 25℃ and pH6

Sicherheit

Kennzeichnung gefährlicher	F,T,Xi
R-Sätze:	11-23/24/25-39/23/24/25-36
S-Sätze:	7-16-36/37-45-26
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
RTECS-Nr.	GV8872620
HS Code	29225090
Giftige Stoffe Daten	93413-62-8(Hazardous Substances Data)

Gefahreninformationscode (GHS)

O-Desmethylvenlafaxine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Desvenlafaxine is a new member of the SNRI class of antidepressants. It is marketed as an extended release tablet for once-daily oral treatment of MDD in adult patients. Desvenlafaxine (O-desmethylvenlafaxine) is the major active metabolite of the previously marketed antidepressant venlafaxine (Effexor). Similar to venlafaxine, desvenlafaxine is a more potent inhibitor of serotonin and norepinephrine reuptake (IC₅₀＝47 and 531 nM, respectively) than that of dopamine (62% inhibition at 100 mM) in in vitro studies. It does not have significant in vitro affinity for other neurotransmitter reporters such as a1-adrenergic, H1-histaminergic, or muscarine-cholinergic receptors. Desvenlafaxine is marketed as a racemic mixture. Specific pharmacological properties of the enantiomers of desvenlafaxine have not been reported.
Chemische Eigenschaften
White Solid
Originator
Wyeth (United States)
Verwenden
A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant
Verwenden
a metabolite of Venlafaxine .;Labeled Venlafaxine, intended for use as an internal standard for the quantification of Venlafaxine by GC- or LC-mass spectrometry.
Verwenden
A metabolite of Venlafaxine (V120000), a selective serotonin noradrenaline reuptake inhibitor (SNRI). Used as an antidepressant.
Definition
ChEBI: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-hydroxyphenyl group. It is a metabolite of the drug venlafaxine.
Trademarks
Pristiq
Allgemeine Beschreibung
An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq^? for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor^? or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
Synthese
Desvenlafaxine is chemically derived from 4-benzyloxyphenylacetic acid, by first converting to the acid chloride with oxalyl chloride and then condensing with dimethylamine to produce the corresponding N,N-dimethyl amide. Deprotonation of the amide with butyllithium, followed by condensation with cyclohexanone gives a b-hydroxyamide intermediate, which is reduced with alane, and debenzylated by using palladium on carbon and 1,4-cyclohexadiene to produce desvenlafaxine.

O-Desmethylvenlafaxine Upstream-Materialien And Downstream Produkte

O-Desmethylvenlafaxine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

93413-62-8, O-Desmethylvenlafaxine Verwandte Suche:

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