8-Anilinonaphthalin-1-sulfonsure

Bezeichnung:8-Anilinonaphthalin-1-sulfonsure

CAS-Nr82-76-8

Englisch Name:8-Anilino-1-naphthalenesulfonic acid

CBNumberCB8289935

SummenformelC16H13NO3S

Molgewicht299.34

MOL-Datei82-76-8.mol

Synonyma

8-Anilinonaphthalin-1-sulfonsure

8-Anilinonaphthalin-1-sulfonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	215-217 °C (dec.)(lit.)
Dichte	1.409±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMF: soluble50mg/mL
pka	0.19±0.40(Predicted)
Aggregatzustand	Powder
Farbe	Dark green to brown to black
Merck	13,664
BRN	1843887
InChI	InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)
InChIKey	FWEOQOXTVHGIFQ-UHFFFAOYSA-N
SMILES	C1(S(O)(=O)=O)=C2C(C=CC=C2NC2=CC=CC=C2)=CC=C1
CAS Datenbank	82-76-8(CAS DataBase Reference)
EPA chemische Informationen	8-Anilino-1-naphthalenesulfonic acid (82-76-8)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36-36/37/38
S-Sätze:	26-36
WGK Germany	-
TSCA	Yes
HS Code	29214980

Gefahreninformationscode (GHS)

8-Anilino-1-naphthalenesulfonic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
1,8-ANS is a fluorescent dye that binds with high affinity to hydrophobic surfaces of proteins. 1,8-ANS has an excitation maximum of 350 nm. It has an emission maximum of 520 nm when free in solution but undergoes a blue shift with an increase in fluorescence intensity when bound to protein; for example, when bound to intestinal fatty acid binding protein (FABP2) it has emission maxima of 468-477 nm. 1,8-ANS binds to low polarity regions of protein surfaces making it well suited for determining the affinity of hydrophobic ligands to their corresponding binding proteins, such as the binding of free fatty acids to FABPs. 1,8-ANS binds to FABP2 with a K_d value of approximately 9.7 μM at 24.5°C.
Chemische Eigenschaften
green needles
Verwenden
Intermediate of dyestuff
Verwenden
8-Anilino-1-naphthalenesulfonic Acid is used as a fluorescent probe to identify hydrophobic sites. Dyes and metabolites.
Definition
CHEBI:8-anilinonaphthalene-1-sulfonic acid is a naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8. It has a role as a fluorescent probe. It is an aminonaphthalene and a naphthalenesulfonic acid.
Biotechnological Applications
8-Anilino-1-naphthalenesulfonic acid is a fluorescent dye with high affinity towards hydrophobic surfaces of proteins. It is useful for determining the affinity of hydrophobic ligands to their corresponding binding proteins. 8-Anilino-1-naphthalenesulfonic acid undergoes a blue shift and fluorescence increases when it binds to non-polar regions of a protein surface or membranes. Used as a probe to monitor protein-folding.

8-Anilino-1-naphthalenesulfonic acid Upstream-Materialien And Downstream Produkte

8-Anilinonaphthalin-1-sulfonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

82-76-8, 8-Anilino-1-naphthalenesulfonic acid Verwandte Suche:

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