Ethyl (R)-3-hydroxybutyrate Struktur

Ethyl (R)-3-hydroxybutyrate

Bezeichnung:Ethyl (R)-3-hydroxybutyrate

CAS-Nr24915-95-5

Englisch Name:Ethyl (R)-3-hydroxybutyrate

CBNumberCB8214494

SummenformelC6H12O3

Molgewicht132.16

MOL-Datei24915-95-5.mol

Ethyl (R)-3-hydroxybutyrate physikalisch-chemischer Eigenschaften

alpha	-45.5 º (589nm, c=1, CHCl3)
Siedepunkt	75-76 °C/12 mmHg (lit.)
Dichte	1.017 g/mL at 25 °C (lit.)
Dampfdruck	17.2Pa at 20℃
Brechungsindex	n20/D 1.42(lit.)
Flammpunkt	148 °F
storage temp.	2-8°C
Aggregatzustand	Liquid
pka	14.45±0.20(Predicted)
Wichte	1.017
Farbe	Clear, Colorless
Optische Aktivität	[α]20/D 46°, c = 1 in chloroform
Wasserlöslichkeit	soluble
LogP	0.341 at 20℃
CAS Datenbank	24915-95-5(CAS DataBase Reference)

Sicherheit

R-Sätze:	36/37/38-52
S-Sätze:	24/25
RIDADR	1993
WGK Germany	3
HS Code	29181990

Gefahreninformationscode (GHS)

Ethyl (R)-3-hydroxybutyrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.
Chemische Eigenschaften
clear colorless liquid
Verwenden
Ethyl (R)-(-)-3-hydroxybutyrate is a chiral building block for the preparation of bioactive compounds used in the pharmaceutical industry. It is formed during the hydrolysis of poly-3-hydroxybutyrate.
Definition
ChEBI: Ethyl (R)-3-hydroxybutanoate is an ethyl 3-hydroxybutyrate. It is functionally related to a (R)-3-hydroxybutyric acid.
Allgemeine Beschreibung
Ethyl (R)-3-hydroxybutyrate is an enantiomer of 3-hydroxybutyric acid. It is synthesized from diethyl succinate in a one-pot, stereoselective, high-yield process by using asymmetric synthesis and hydrogenation. The reaction vessel used for this synthesis is a reaction solution that has been optimized to be resistant to high pressure and temperature. This product can be used as a renewable feedstock in the production of polyesters and other polymers.
Synthese
(R)-β-Butryrolactone (20 g, 230 mmol) was dissolved in 500 mLethanol with 1.0 mL H2SO4 and stirred at room temperature. Aliquots(100 μL) were added to 1.0 mL of methanol and analyzed by GC-MS for conversion of the lactone. Upon completion (> 48 h), a small amount of solid sodium bicarbonate was added and the solvent removed by rotary evaporation. The residue was taken up in dichloromethane and washed with water. The water layer was extracted twice with ethyl acetate. The pooled organic layers were dried with magnesium sulfate, which was then filtered and the solvent removed by rotary evaporation to yield Ethyl (R)-3-hydroxybutyrate as a clear oil (20.2 g, 66%).

Ethyl (R)-3-hydroxybutyrate Upstream-Materialien And Downstream Produkte

Ethyl (R)-3-hydroxybutyrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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