Tributyl-O-acetylcitrat

Bezeichnung:Tributyl-O-acetylcitrat

CAS-Nr77-90-7

Englisch Name:Acetyl tributyl citrate

CBNumberCB0408022

SummenformelC20H34O8

Molgewicht402.48

MOL-Datei77-90-7.mol

Synonyma

Tributyl-O-acetylcitrat

Tributyl-O-acetylcitrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	-59 °C
Siedepunkt	327 °C
Dichte	1.05 g/mL at 25 °C (lit.)
Pour Point	-43
Dampfdruck	0.26 psi ( 20 °C)
Brechungsindex	n20/D 1.443(lit.)
FEMA	3080 \| TRIBUTYL ACETYLCITRATE
Flammpunkt	>230 °F
storage temp.	Store below +30°C.
Löslichkeit	Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
Aggregatzustand	Liquid
Farbe	Clear Colourless
Geruch (Odor)	at 100.00 %. very faint herbal wine sweet
Geruchsart	herbal
Biologische Quelle	synthetic
Wasserlöslichkeit	<0.1 g/100 mL
FreezingPoint	-80℃
JECFA Number	630
BRN	2303316
Henry's Law Constant	2.6×10⁴ mol/(m³Pa) at 25℃, HSDB (2015)
Kosmetik-Inhaltsstoffe Funktionen	FRAGRANCE PERFUMING PLASTICISER
Erinnerung an die inhaltsstoffe	Acetyl tributyl citrate (77-90-7)
InChI	1S/C20H34O8/c1-5-8-11-25-17(22)14-20(28-16(4)21,19(24)27-13-10-7-3)15-18(23)26-12-9-6-2/h5-15H2,1-4H3
InChIKey	QZCLKYGREBVARF-UHFFFAOYSA-N
SMILES	CCCCOC(=O)CC(CC(=O)OCCCC)(OC(C)=O)C(=O)OCCCC
LogP	5.227 (est)
CAS Datenbank	77-90-7(CAS DataBase Reference)
NIST chemische Informationen	1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA chemische Informationen	Acetyl tributyl citrate (77-90-7)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
RTECS-Nr.	TZ8330000
TSCA	TSCA listed
HS Code	29181500
Speicherklasse	10 - Combustible liquids
Giftige Stoffe Daten	77-90-7(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Acetyl tributyl citrate Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.
Chemische Eigenschaften
clear colorless liquid
Chemische Eigenschaften
Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.
Chemische Eigenschaften
Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.
Verwenden
plasticizer flavoring agent
Verwenden
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Verwenden
Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.
Definition
Aqueous-based pharmaceutical coat- ings.
Vorbereitung Methode
Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.
synthetische
From citric acid via the tributyl ester followed by acetylation.
Taste threshold values
An emulsion of the title material in water at 1000 ppm has only a very faint, mildly fruity-winey, berry-like odor and a mild, nondescript taste.
Allgemeine Beschreibung
Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmazeutische Anwendungen
Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.
Sicherheitsprofil
When heated to decomposition it emits acrid smoke and irritating fumes. ADD750
Sicherheit(Safety)
and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD₅₀ (cat, oral): >50 mL/kg
LD₅₀ (mouse, IP): >4 g/kg
LD₅₀ (rat, oral): >31.5 g/kg
Carcinogenicity
The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.
Solubility in organics
Miscible with alcohol and oils.
Lager
Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.
Inkompatibilitäten
Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.
Regulatory Status
Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Acetyl tributyl citrate Upstream-Materialien And Downstream Produkte

Tributyl-O-acetylcitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

77-90-7, Acetyl tributyl citrate Verwandte Suche:

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