Natrium-(-)-2-(6-methoxy-2-naphthyl)propionat

Bezeichnung:Natrium-(-)-2-(6-methoxy-2-naphthyl)propionat

CAS-Nr26159-34-2

Englisch Name:Naproxen sodium

CBNumberCB8114925

SummenformelC14H13O3.Na

Molgewicht252.24

MOL-Datei26159-34-2.mol

Synonyma

Natrium-(-)-2-(6-methoxy-2-naphthyl)propionat

Natrium-(-)-2-(6-methoxy-2-naphthyl)propionat physikalisch-chemischer Eigenschaften

Schmelzpunkt	250-251°C
alpha	D -11° (in methanol)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
Aggregatzustand	Solid
Farbe	White to Off-White
Wasserlöslichkeit	Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
CAS Datenbank	26159-34-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	22-61
S-Sätze:	53-45
RIDADR	3249
WGK Germany	3
RTECS-Nr.	QJ1047000
HazardClass	6.1(b)
PackingGroup	III
HS Code	2918992090

Gefahreninformationscode (GHS)

Naproxen sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
Chemische Eigenschaften
White Powder
Verwenden
A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout.
Verwenden
Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively
Verwenden
An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory
Definition
ChEBI: The sodium salt of naproxen.
Trademarks
Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).
Allgemeine Beschreibung
Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biologische Aktivität
Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.
Biochem/physiol Actions
Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
Einzelnachweise
[1]. mendias cl, tatsumi r and allen re. role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. muscle nerve, 2004, 30(4):497-500.
[2]. hinz b, cheremina o, besz d, et al. impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. int j clin pharmacol ther, 2008, 46(4):180-6.
[3]. sances g, martignoni e, fioroni l, et al. naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. headache, 1990, 30(11):705-9.
[4]. tavolari s, bonafè m, marini m, et al. licofelone, a dual cox/5-lox inhibitor, induces apoptosis in hca-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. carcinogenesis, 2008, 29(2):371-80.

Naproxen sodium Upstream-Materialien And Downstream Produkte

Natrium-(-)-2-(6-methoxy-2-naphthyl)propionat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

26159-34-2, Naproxen sodium Verwandte Suche:

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