Oxymetazoline hydrochloride

Bezeichnung:Oxymetazoline hydrochloride

CAS-Nr2315-02-8

Englisch Name:Oxymetazoline hydrochloride

CBNumberCB7157390

SummenformelC16H25ClN2O

Molgewicht296.84

MOL-Datei2315-02-8.mol

Oxymetazoline hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	approximate 300℃ (dec.)
storage temp.	Store at RT
Löslichkeit	H₂O: soluble
Aggregatzustand	solid
Farbe	white
PH	pH (50g/L, 25℃) : 4.0～6.5
Wasserlöslichkeit	Soluble to 50 mM in water
Stabilität	Toxic
CAS Datenbank	2315-02-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T+
R-Sätze:	28
S-Sätze:	22-28-36/37/39-45
RIDADR	UN 2811 6.1/PG 1
WGK Germany	3
RTECS-Nr.	SK1225000
HazardClass	6.1(a)
PackingGroup	II
HS Code	2933290000
Toxizität	LD50 orally in mice: 10 mg/kg (Hotovy)

Gefahreninformationscode (GHS)

Oxymetazoline hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R28:Sehr giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Off-White Solid
Originator
Nasivin,Merck,W. Germany ,1961
Verwenden
muscle relaxant (smooth), cerebral vasodilator
Verwenden
Oxymetazoline hydrochloride is an α1-AR and α2-AR adrenergic receptor agonist and used as Vasoconstrictor, a nasal decongestant.
Verwenden
Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin.
Definition
ChEBI: A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal con estion.
Manufacturing Process
10 grams 2,6-dimethyl-3-hydroxy-4-tertiary butylbenzylcyanide (produced by chloromethylation of 2,4-dimethyl-6-tertiary butyl-phenol with formaldehyde and HCl and conversion of the substituted benzyl chloride with NaCN; crystals, from alcohol, melting at 135° to 137°C) and 10.7 grams ethylenediaminemono-p-toluenesulfonate are heated in an oil bath to approximately 235°C for 1? hours, whereby ammonia is evolved. The free base is obtained from the p-toluene-sulfonic acid imidazoline salt which is difficultly soluble in water, by conversion with 50 cc of a 10% NaOH solution. Said base is recrystallized from benzene, and 7.5 grams (62% of the theoretical yield) 2-(2',6'-dimethyl3'-hydroxy-4'-tertiary butylbenzyl)-2-imidazoline, MP 180° to 182°C, are obtained.
By dissolving the free base in an ethyl alcohol solution of hydrochloric acid and adding ether, the hydrochloride can be produced in the usual manner. Said hydrochloride melts, when recrystallized from alcoholic ether, at 300° to 303°C and is decomposed
Trademarks
Ocuclear (Schering-Plough); Visine (Pfizer).
Therapeutic Function
Nasal decongestant
Biologische Aktivität
Partial α 2A adrenoceptor agonist and α 1A agonist. Agonist/antagonist activity at 5-HT receptors.

Oxymetazoline hydrochloride Upstream-Materialien And Downstream Produkte

2315-02-8, Oxymetazoline hydrochloride Verwandte Suche:

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