Flopropion

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P321：Besondere Behandlung

  P332+P313：Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

  P362：Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen.

Flopropione Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

• Verwenden

  antispasmodic

• Definition

  ChEBI: Flopropione is an organic molecular entity.

• synthetische

  Preparation by reaction of propionitrile with phlo-roglucinol (Hoesch reaction);
  Preparation by reaction of propionic anhydride with phloroglucinol
  in the presence of concentrated sulfuric acid (one drop) at 130° for 5 min (65%)
  in the presence of Amberlite IR-120 (cation exchange resin sulfonic acid type) at 160° for 2–3 h (42%). N.B.: Zeokarb 225 was found to be as effective
  in the presence of boron trifluoride etherate at 10° (62–65%)
  Preparation by reaction of propionyl chloride with phloroglucinol
  in the presence of aluminium chloride in nitrobenzene/carbon disulfide solution (76%), in nitrobenzene at 60° (55%) or without solvent at 50° (70%)
  in the presence of boron trifluoride etherate at 10° (compound 3) (62–65%).

• Synthese

  

  108-73-6

  

  79-03-8

  

  2295-58-1

  General procedure: Anhydrous AlCl3 (4 eq.) was slowly added to a stirred suspension of resorcinol (1 eq.) in CS2. Subsequently, nitrobenzene was added dropwise over 30 minutes. The reaction mixture was refluxed at 55 °C for 30 min. Next, propionyl chloride (1 eq.) dissolved in nitrobenzene was slowly added over 30 min and the reaction mixture continued to be heated for 30 min. Upon completion of the reaction, the mixture was allowed to cool to room temperature with stirring, followed by slow pouring into an ice water bath. 3M HCl was added to quench the reaction. The organic solvent was removed by distillation under reduced pressure and the resulting oily residue was extracted with Et2O. After extraction, Et2O was removed by evaporation and the crude product was purified by fast chromatography (eluent: petroleum ether (boiling point 50-70 °C)/ethyl acetate, ratio tapered from 5:1 to 3:1).

• in vivo

  The effect of Flopropione as an antispasmodic agent on the rate of passing a calculus from the urinary tract has been compared retrospectively with patients in whom passage was spontaneous. Flopropine has been shown, with statistical significance, to be superior to the control in cumulative passage rate after initiation of administration. Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems^[3].

• IC 50

  5-HT_1A Receptor; COMT

• Einzelnachweise

  [1] Agricultural and Biological Chemistry, 1985, vol. 49, # 3, p. 719 - 724
  [2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 621 - 628
  [3] Australian Journal of Chemistry, 2005, vol. 58, # 7, p. 551 - 555
  [4] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 255 - 262
  [5] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 13, p. 4402 - 4409

Flopropione Upstream-Materialien And Downstream Produkte

Flopropion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(118)Suppliers

2295-58-1, Flopropione Verwandte Suche: