Fenoldopam

Bezeichnung:Fenoldopam

CAS-Nr67227-56-9

Englisch Name:Fenoldopam

CBNumberCB6729842

SummenformelC16H16ClNO3

Molgewicht305.76

MOL-Datei67227-56-9.mol

Fenoldopam physikalisch-chemischer Eigenschaften

Siedepunkt	522.6±50.0 °C(Predicted)
Dichte	1.380±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: >12 mg/mL
pka	8.50±0.40(Predicted)
Aggregatzustand	Powder
Farbe	off-white
CAS Datenbank	67227-56-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36-42/43
S-Sätze:	22-26-36/37/39
WGK Germany	3

Fenoldopam Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Originator
Corlopam,Pharmaforce, Inc.
Verwenden
The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. Fenoldopam is a selective dopamine 1 receptor agonist with diuretic and properties (2,3).
Verwenden
dopamine receptor agonists
Verwenden
Dopamine D1-receptor agonist. Antihypertensive.
Definition
ChEBI: Fenoldopam is a benzazepine. It has a role as a dopaminergic antagonist, a vasodilator agent, an alpha-adrenergic agonist, a dopamine agonist and an antihypertensive agent.
Manufacturing Process
2-Chloro-3,4-dimethoxyphenethylamine (1.0 g) was reacted with 0.70 g of pmethoxystyrene oxide to give the hydroxyphenethylamine; m.p. 118.5-121°C. This compound (2.16 g) was stirred at room temperature in 15 ml of trifluoroacetic acid with 4 drops of conc. sulfuric acid. After purification over a silica gel column with chloroform, 10% methanol/chloroform as eluates, was obtained 6-chloro-7,8-dimethoxy-1-p-methoxyphenyl-2,3,4,5-tetrahydro-1H- 3-benzazepine (0.78 g), m.p. 143-145°C.
The trimethoxy product (0.87 g, 2.50 mmoles) in 25 ml of dry methylene chloride was cooled in an ice-methanol bath and 12.5 ml (25.0 mmoles) of boron tribromide in methylene chloride was added dropwise. After stirring for 4 hours, the mixture was cooled in an ice bath while methanol was carefully added to give 0.37 g of 6-chloro-7,8-dihydroxy-1-p-hydroxyphenyl-2,3,4,5- tetrahydro-1H-3-benzazepine hydrobromide, m.p. 215°C.
The base was regenerated from the hydrobromide salt using sodium carbonate solution in 85% yield. Treating the base with various acids gave the following salts: dl-tartrate, fumarate, hydrochloride, sulfate, and the most water soluble one, the methanesulfonate, m.p. 272°C.
Trademarks
Corlopam (Hospira).
Therapeutic Function
Antihypertensive
Biologische Aktivität
Selective D 1 -like dopamine receptor partial agonist (EC 50 = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α 2 -adrenoceptor antagonist in vitro (K i = 15-25 nM).

Fenoldopam Upstream-Materialien And Downstream Produkte

Fenoldopam Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

67227-56-9, Fenoldopam Verwandte Suche:

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