Estramustin

Bezeichnung:Estramustin

CAS-Nr2998-57-4

Englisch Name:Estramustine

CBNumberCB9127416

SummenformelC23H31Cl2NO3

Molgewicht440.4

MOL-Datei2998-57-4.mol

Synonyma

Estramustin

Estramustin physikalisch-chemischer Eigenschaften

Schmelzpunkt	104-105°
alpha	D20 +50° (in dioxane)
Siedepunkt	565.8±50.0 °C(Predicted)
Dichte	1.253±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	15.05±0.40(Predicted)
Wasserlöslichkeit	1mg/L(30 ºC)
CAS Datenbank	2998-57-4(CAS DataBase Reference)

Gefahreninformationscode (GHS)

Estramustine Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Estradiol 3-[N,N-Bis(2-chloroethyl)carbamate] is used treatment of breast cancer. Also used in the treatment of prostate cancer.
Verwenden
Antineoplastic.
Definition
ChEBI: A carbamate ester obtained by the formal condensation of the hydroxy group of 17beta-estradiol with the carboxy group of bis(2-chloroethyl)carbamic acid.
Indications
Estramustine phosphate sodium (Emcyt) is a hybrid structure combining estradiol and a nitrogen mustard in a single molecule. The drug has been approved for use in prostatic carcinomas and will produce clinical remissions in one-third of patients who have failed to respond to previous estrogen therapy. The mechanism of action of estramustine is not well defined, but it does not appear to require either alkylation of DNA or the presence of estrogen receptors in tumor cells. Nonetheless, the toxicities of the drug are similar to those of estrogen therapy: breast tenderness and enlargement (gynecomastia), fluid retention, mild nausea, and an increased risk of thrombophlebitis and pulmonary embolism.The drug is not myelosuppressive.
Biologische Funktion
Estramustine has a low affinity for the βm tubulin isotype, which often is overexpressed in estramustineresistant prostatic neoplasms as one defense against this therapeutic intervention.
Mechanism of action
Because this anticancer agent contains a carbamylated nitrogen mustard moiety, it is most commonly classified as a DNA alkylator; however, it is now known that its primary mechanism of antineoplastic action is inhibition of mitosis.

Estramustine Upstream-Materialien And Downstream Produkte

Estramustin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2998-57-4, Estramustine Verwandte Suche:

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