3,4-Dimethoxyphenethylamine Struktur

3,4-Dimethoxyphenylethylamin

Bezeichnung:3,4-Dimethoxyphenylethylamin

CAS-Nr120-20-7

Englisch Name:3,4-Dimethoxyphenethylamine

CBNumberCB4294076

SummenformelC10H15NO2

Molgewicht181.23

MOL-Datei120-20-7.mol

Synonyma

3,4-Dimethoxyphenethylamin

3,4-Dimethoxyphenylethylamin

3,4-Dimethoxyphenylethylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	12-15 °C
Siedepunkt	188 °C15 mm Hg(lit.)
Dichte	1.074 g/mL at 25 °C(lit.)
Dampfdruck	0.348-0.348Pa at 25℃
Brechungsindex	n20/D 1.546(lit.)
Flammpunkt	>230 °F
storage temp.	Refrigerator
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Viscous Liquid
pka	9.74±0.10(Predicted)
Wichte	1.10
Farbe	Clear light yellow to orange or slightly brownish
PH	11.4 (100g/l, H2O, 20℃)
Explosionsgrenze	0.1-1.7%(V)
Wasserlöslichkeit	SOLUBLE
Sensitive	Air Sensitive
InChIKey	ANOUKFYBOAKOIR-UHFFFAOYSA-N
LogP	0.77
CAS Datenbank	120-20-7(CAS DataBase Reference)
NIST chemische Informationen	Benzeneethanamine, 3,4-dimethoxy-(120-20-7)
EPA chemische Informationen	Benzeneethanamine, 3,4-dimethoxy- (120-20-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-36/37/38
S-Sätze:	26-36-37/39
RIDADR	UN 2735
WGK Germany	3
RTECS-Nr.	SH2300000
F	10
Hazard Note	Irritant
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29222900
Toxizität	mouse,LD50,intraperitoneal,181mg/kg (181mg/kg),Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.

Gefahreninformationscode (GHS)

3,4-Dimethoxyphenethylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
3,4-Dimethoxyphenylethylamine, also known as 3,4-DMPEA or DMPEA is an endogenous metabolite found in urine that belongs to both the phenethylamine and catecholamine families. DMPEA is an analogue of dopamine (3,4-dihydroxyphenethylamine), with a substitution of the hydroxy groups with methoxy groups. It is also structurally similar to mescaline (3,4,5-trimethoxyphenylethylamine) and occurs naturally alongside it in various species of cacti such as the San Pedro and Peruvian Torch. DMPEA received wide attention after it was proposed as a biomarker in schizophrenic patients urine, however later studies revealed that DMPEA is also excreted by non-schizophrenics. DMPEA has little known bioactivity, but it has some action as a monoamine oxidase inhibitor. It has also been shown to have neurotoxic effects, especially in the nigrostriatal system and among dopaminergic neurons. DMPEA appears to be an inhibitor of mitochondrial complex I.
Chemische Eigenschaften
3,4-Dimethoxyphenethylamine is clear yellowish oil
Occurrence
3,4-Dimethoxyphenethylamine is a natural product found in Pilosocereus leucocephalus, Vachellia rigidula, and Ototropis elegans with data available.
Verwenden
3,4-Dimethoxyphenethylamine is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies.
Verwenden
Precursor for the synthesis of isoquinolines.
Definition
ChEBI: An aromatic ether that is the derivative of 2-phenylethylamine with methoxy substituents at the 3- and 4-positions. It is an alkaloid isolated from the Cactaceae family.
Flammability and Explosibility
Not classified
Sicherheitsprofil
Poison by intravenous and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
läuterung methode
Purify the amine by fractionation through an efficient column in an inert atmosphere as it is a relatively strong base. [Horner & Sturm Justus Liebigs Ann Chem 608 12819 1957, Jung et al. J Am Chem Soc 75 4664 1953.] The hydrochloride has m 152o, 154o, 156o (from EtOH, Me2CO or EtOH/Et2O), the picrate has m 165-167o(dec), and the 4-nitrobenzoyl derivative has m 147o [Buck J Am Chem Soc 55 2593 1933]. [Beilstein 13 H 800, 13 IV 2604.]

3,4-Dimethoxyphenethylamine Upstream-Materialien And Downstream Produkte

3,4-Dimethoxyphenylethylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

120-20-7, 3,4-Dimethoxyphenethylamine Verwandte Suche:

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