Brucin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H300：Lebensgefahr bei Verschlucken.

  H330：Lebensgefahr bei Einatmen.

  H412：Schädlich für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P320：Besondere Behandlung dringend erforderlich

  P330：Mund ausspülen.

  P405：Unter Verschluss aufbewahren.

10,11-Dimethoxystrychnine Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE KRISTALLE ODER WEISSES KRISTALLINES PULVER.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Stickstoffoxiden. Schwache Base in wässriger Lösung. Reagiert mit starken Oxidationsmitteln unter Feuer- und Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Reizt möglicherweise mechanisch. Möglich sind Auswirkungen auf Nervensystem und Augen mit nachfolgenden Krämpfen und Atemlähmung. Exposition kann zum Tod führen.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P3-Filter für giftige Partikel. NICHT in die Umwelt gelangen lassen.

• R-Sätze Betriebsanweisung:

  R26/28:Sehr giftig beim Einatmen und Verschlucken.
  R52/53:Schädlich für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S13:Von Nahrungsmitteln, Getränken und Futtermitteln fernhalten.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Aussehen Eigenschaften

  C23H26N2O4; Dimethoxystrychnin; weiße, geruchlose, wenig wasserlösliche Kristalle.

• Gefahren für Mensch und Umwelt

  Bildet als Zersetzungsprodukte nitrose Gase (NO_x).
  Brucin wirkt bereits bei geringen Mengen als Nervengift. Vergiftungsgefahr besteht neben Einatmen und Verschlucken auch durch Hautresorption. Lungenödem und zentrale Atemlähmung möglich. Besondere Gefährdung für Herz-, Nieren- und Leberkranke.
  Stark wassergefährdender Stoff.

• Schutzmaßnahmen und Verhaltensregeln

  #
  Schutzhandschuhe aus Gummi (nur als kurzzeitiger Staub- und Spritzschutz).

• Verhalten im Gefahrfall

  Vorsichtig trocken aufnehmen. Staubentwicklung vermeiden. Nachreinigen. Als Sondermüll entsorgen.
  Wasser, Schaum, Kohlendioxid, Pulver.
  Bei Brand können Stickoxide (NO_x) freigesetzt werden.

• Erste Hilfe

  Nach Hautkontakt: Sofort mit viel Wasser abwaschen.
  Nach Augenkontakt: Gründlich mit viel Wasser bei geöffnetem Lispalt mindestens 10 Minuten spülen. Augenarzt konsultieren.
  Nach Einatmen: Frischluft. Bei Atemstillstand Atemspende oder Gerätebeatmung. Sofort Arzt hinzuziehen.
  Nach Verschlucken: Viel Wasser trinken lassen. Erbrechen auslösen. Sofort Arzt hinzuziehen.
  Nach Kleidungskontakt: Kontaminierte Kleidung sofort ausziehen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll entsorgen.

• Beschreibung

  As a Chinese medicine, brucine was firstly recorded in Compendium of Materia Medica. The Chinese name for brucine is “Maqian” because it looks like ancient coins with horse icon, where “Ma” refers to “horse” and “qian” refers to “coins.” This traditional Chinese herb has cold, bitter, and toxic properties. It can be used to treat typhoid fever, throat pain, and lumps. Brucine is mainly extracted from the traditional Chinese medicine “Maqian.” In 1819, Pelletier and Caventou firstly isolated the alkaline brucine from the seeds and bark of Strychnos nux-vomica L.?Brucine is the dry and mature seeds of Loganiaceae Evergreen tree plants including Strychnos nux-vomica L. and Strychnos pierriana A.W. Hill.

• Chemische Eigenschaften

  White powder

• Physikalische Eigenschaften

  Appearance: white crystalline powder; tastes very bitter. Solubility: slightly soluble in water; soluble in ether, chloroform, ethanol, methanol, and other organic solvents . Melting point: 175–178?°C. Specific optical rotation: ?118°.

• Verwenden

  Brucine is used as a denaturing alcohol, lubricant additive, separation of racemic mixtures. Proposed to reduce inflammatory mediators including COX-2, PGE2 and thromboxane B2. Able to induce cell apoptosis, with cytotoxic and antiproliferative effects.

• Verwenden

  Brucine occurs in the seeds of strychnosspecies (Strychnos nux vomica L. and otherspecies). It is used for denaturing alcoholsand oils; for separating racemic mixtures;and as an additive to lubricants. It is alsoused for colorimetric analysis of nitrate.Therapeutically, it is used as a stimulant.

• Verwenden

  10,11-Dimethoxystrychnine can be used for antineoplastic, convulsant.

• Definition

  ChEBI: Brucine is a monoterpenoid indole alkaloid and an organic heteroheptacyclic compound.

• Allgemeine Beschreibung

  A white crystalline solid. Combustible but may require some effort to ignite. Toxic by inhalation (vapor, dust, etc.) and ingestion.

• Air & Water Reaktionen

  Slightly soluble in water.

• Hazard

  Poison by ingestion and inhalation.

• Health Hazard

  Chemical is toxic if inhaled, swallowed, or absorbed through skin. Inhalation produces intense bitter taste. Ingestion causes nausea, vomiting, restlessness, excitement, twitching, and (rarely) convulsions. Contact with dust irritates eyes.

• Health Hazard

  The toxicity of brucine is similar to that ofstrychnine. It is a very poisonous alkaloid. Itis a strong convulsant; excites all portions ofthe central nervous system. Toxic symptomsinclude headache, tremor, muscular rigidity,and convulsions. Death may occur fromrespiratory arrest after a few convulsions.
  LD50 value, subcutaneous (mice): 60 mg/kg.

• Brandgefahr

  Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.

• Landwirtschaftliche Anwendung

  Rodenticide: Used in the manufacture of other chemicals, in perfumes, as a medication for animals, and as a poison for rodents

• Handelsname

  DOLCO MOUSE CEREAL®; PIED PIPER MOUSE SEED® (Brucine)

• Pharmakologie

  1. Analgesic effects: Brucine is reported to exert analgesic effects through both central and peripheral pathways. Possible mechanisms of the analgesic effects include blocking the voltage-gated sodium channel, inhibiting the synthesis of PGE2, acting on the adrenergic receptor and the L-arginine-NO pathway. Brucine (0.48?mg/kg) can significantly elevate the pain threshold in mice.
  2. Anti-tumor effects: Studies have shown that brucine inhibits the cell proliferation in breast cancer, liver cancer, leukemia, and Ehrlich ascites tumors by inducing tumor cell apoptosis, inhibiting angiogenesis, reversing tumor multidrug resistance, and regulating the expression of various cytokines. In addition, at the dose of 320?μg/ml, the in?vitro hepatocarcinoma cell growth inhibition rate of brucine is nearly 100%.
  3. Anti-pathogen effects: In vitro study shows that 0.1% brucine can completely inhibit the growth of Haemophilus influenzae, Streptococcus pneumoniae, and alpha Streptococcus and Mlicrococcus catarrhalis. At the dose of 500?μg/ml, the inhibitory rate of brucine on human immunodeficiency virus reverse transcriptase is above 30%.
  4. Other pharmacological effects: Anti-inflammation, regulation of the immune system, regulation of the cardiovascular system, antitussive, expectorant, and antiasthenic and antibacterial effects.

• Clinical Use

  The applications of brucine include reducing swelling; resolving mass; activating meridians to stop pain; attenuating rheumatism, stubborn paralysis, and numbness paralysis; alleviating bruises; etc. It has been used for nearly a thousand years and achieved prominent clinical efficacy. In the clinical practice, brucine is used as a compatibility prescription or compound medicine in treating rheumatism, rheumatoid arthritis, stroke hemiplegia, dementia, retinopathy, and orthopedic and other surgical diseases.
  Brucine is the main active ingredient in Strychnos and plays an important role in treating diseases. However, brucine is also a toxic ingredient, which limits the scope of its clinical application. Further studies of its pharmacological effects and toxicity will improve its clinical application.

• Sicherheitsprofil

  A poison by subcutaneous, intravenous, and intraperitoneal routes. An alkaloid-like strychnine, but one-sixth as toxic. When heated to decomposition it emits toxic fumes of Nx,. See also STRYCHNINE

• mögliche Exposition

  Drug, NaturalProduct. Brucine is used as denaturant for Ethanol, alsoresolving agent for isomer separation; in the manufacture ofother chemicals, in perfumes, as a medication for animals,and as a poison for rodents. It is an alkaloid, produced fromstrychnos seeds.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

• Lager

  Color Code—Blue: Health Hazard: Store in asecure poison location. Protect against physical damage.Outside or detached storage is preferred. Color Code—Blue: Health Hazard/Poison: Store in a secure poison location. Prior to working with brucine you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area away from strongoxidizers.

• Versand/Shipping

  Label: “POISONOUS/TOXIC MATERIALS.” Itfalls in Hazard Class 6.1 and Packing Group I.

• läuterung methode

  Crystallise brucine once from water or aqueous Me2CO (as the tetrahydrate), then suspend it in CHCl3 and shake with anhydrous Na2SO4 (to dehydrate the brucine, which then dissolves). Precipitate it by pouring the solution into a large bulk of dry pet ether (b 40-60o), filter and heat to 120o in a high vacuum [Turner J Chem Soc 842 1951]. The tetrahydrate crystallises from a mixture of EtOH and H2O as colourless elongated needles [Eeles Acta Cryst 6 809 1953, Beilstein 27 III/IV 7875.] VERY POISONOUS

• Inkompatibilitäten

  Reacts with strong oxidizers. Finely dispersed material in air can cause dust explosions.

10,11-Dimethoxystrychnine Upstream-Materialien And Downstream Produkte

357-57-3, 10,11-Dimethoxystrychnine Verwandte Suche: