Strychnin

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P262：Nicht in die Augen, auf die Haut oder auf die Kleidung gelangen lassen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

STRYCHNINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  GERUCHLOSE UND FARBLOSE KRISTALLE MIT BITTEREM GESCHMACK.

• CHEMISCHE GEFAHREN

  Zersetzung beim Erhitzen unter Bildung giftiger Rauche mit Stickstoffoxiden. Schwache Base. Reagiert mit starken Oxidationsmitteln unter Feuer- und Explosionsgefahr.

• ARBEITSPLATZGRENZWERTE

  TLV: 0.15 mg/m?(als TWA); (ACGIH 2005).
  MAK: IIb (nicht festgelegt, aber Informationen vorhanden) (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation des Aerosols und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden, vor allem als Pulver.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Möglich sind Auswirkungen auf das Zentralnervensystem mit nachfolgenden Krämpfen, Muskelkontraktionen und Atemversagen. Exposition kann zum Tod führen.

• LECKAGE

  NICHT in die Umwelt gelangen lassen. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R27/28:Sehr giftig bei Berührung mit der Haut und beim Verschlucken.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Aussehen Eigenschaften

  C21H22N2O2; farblose, glänzende, geruchslose Kristallnadeln von sehr bitterem Geschmack.

• Gefahren für Mensch und Umwelt

  Gefährliche Zersetzungsprodukte: Nitrose Gase
  Sehr giftig bei Berührung mit der Haut und beim Verschlucken. 15 mg können beim Erwachsenen zu Krämpfen führen, die tödliche Dosis liegt bei etwa 0.1 - 0.3 g. Es wirkt hautreizend. Vergiftungserscheinungen sind Unruhe, Angst, blaue Gesichtsfarbe, Zuckungen und Starrkrampfanfälle. Das Bewußtsein bleibt während der äußerst schmerzhaften Anfälle voll erhalten. Der Tod tritt durch Krampf der Atemmuskulatur ein.

• Schutzmaßnahmen und Verhaltensregeln

  Im Abzug arbeiten.
  Neoprenschutzhandschuhe nur als kurzzeitiger Staub- und Spritzschutz.

• Verhalten im Gefahrfall

  Vorsichtig mechanisch aufnehmen.
  Wassernebel, Kohlendioxid, Schaum.

• Erste Hilfe

  Nach Hautkontakt: Sofort mit viel Wasser abwaschen.
  Nach Augenkontakt: Gründlich mit viel Wasser mind. 10 Min. spülen. Augenarzt konsultieren.
  Nach Verschlucken: Den Betroffenen nur bei vollem Bewußtsein selbsttätig erbrechen lassen. Sofort Arzt hinzuziehen. Bei Verschlucken Wasser trinken lassen. Sofortige Gabe großer Mengen an medizinischer Kohle (40 - 60 g), die Strychnin sehr gut bindet.
  Nach Kleidungskontakt: Kontaminierte Kleidung sofort ausziehen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Als Sondermüll entsorgen.

• Beschreibung

  Strychnine, C21H22N2O2, Mr 334.4, mp 270–280 ?C (decomp.), forms colorless crystals which are slightly soluble in water, moderately in benzene, ethanol, readily soluble in chloroform [9, p. 1121].

• Chemische Eigenschaften

  Hard white crystals or powder; bitter taste. Soluble in chloroform; slightly soluble in alcohol and benzene; slightly soluble in water and ether.

• Chemische Eigenschaften

  Strychnine is a colorless crystalline prisms or white powder. It is odorless; with a bitter taste

• Physikalische Eigenschaften

  Colorless to white, odorless crystals. Bitter taste.

• History

  Strychnine is a white, odorless, toxic crystalline powder with a bitter taste. Strychnine is a well-known poison, but it has also been used in medications. It was one of the first alkaloids to be isolated in pure form when Joseph Bienaimé Caventou (1795 1877) and Pierre Joseph Pelletier (1788 1842) extracted it from Saint Ignatius beans (Strychnos ignatii) in 1818. Caventou and Pelletier subsequently obtained it from its main source Strychnos nux vomica; it is also found in other Strychnos species. Strychnos nux vomica is an evergreen tree native to east India, Southeast Asia, and northern Australia. The seeds of the plant are the main source of strychnine and several other alkaloids (brucine), but it is also obtained from the bark and roots. The seeds are heated and then ground to a powder that contains strychnine. The brownish-gray powder obtained from the ground seeds extracted from the nut is called nux vomica. In commercial production during the 1800s, the seeds were softened by boiling in a dilute sulfuric acid solution and then dried and ground to a powder. Strychnine was extracted from the powder using alcohol and separation techniques to remove impurities. The structure of strychnine was determined by Robert Robinson (1886 1975) in 1946; the next year Robinson received the Nobel Prize in chemistry for his work on alkaloids. Robert Burns Woodward (1917 1979) performed the first complete synthesis of strychnine in 1953.Strychnine was used in its impure powder form centuries before it was isolated. The nuts that yielded the seeds were given names such as poison nut or vomit nuts. Early workers on its properties warned about its poisonous properties and recommended against it internal use.

• Verwenden

  Strychnine as nux vomica was available in apothecaries throughoutthe 19th century, and strychnine salts such as strychnine sulfate, strychnine nitrate, andstrychnine phosphate were a popular medicine. It was sold as pills, powders, and tinctures.Small quantities of strychnine were added to tonics to serve as stimulants. Because its bittertaste stimulates saliva and gastric production, strychnine was used to counteract the lossof appetite produced by various diseases. Hypodermic injections of strychnine along withdigitalis were prescribed for treating acute heart failure in the early 20th century. Otherconditions for which strychnine was prescribed included paralysis, impotence, alcoholism,and drug addiction.
  Today strychnine as nux vomica is still available as an herbal ingredient for herbal and homeopathic remedies. The action of nux vomica is attributed to strychnine and brucine. It is recommended for stomach ailments such as atonic dyspepsia, constipation, heart burn, and indigestion. It is reported to relieve nausea during pregnancy. Chinese herbalists use nux vomica externally to treat tumors, headaches, and paralysis. It is recommended for the treatment of Bell's palsy. Strychnine has some uses in modern traditional medicine. It has been used to treat the genetic disorder nonketotic hyperglycinaemia (NKH). NKH is related to glycine metabolism; it can lead to high levels of the inhibitory receptor glycine resulting in seizures. Strychnine is used in neurological research by applying it to areas of the brain or spinal column and observing how the nervous system responds. This method is called strychnine neuronography. Strychnine has been used in conjunction with antivenoms to treat poisonous snake bites. Strychnine is sometimes cut into cocaine, heroin, and other illegal substances in the production of designer drugs.
  Strychnine was once used liberally as a pesticide, especially to control vertebrates.It is used as a salt in granular bait formulations. In the United States its use has been progressively limited over the years. . In the1980s, its use was curtailed for above-ground applications to reduce toxicity to nontargetspecies, especially birds; by the end of the decade, its use was limited to below ground.Currently, strychnine is only registered for use by the EPA as a below-ground bait pesticidefor use on pocket gophers.

• Verwenden

  Strychnine occurs in the seeds of strychnosspecies (S. nux vomica L., S. Loganiaceae,and S. ignatii Berg). The total alkaloid con tent in these plants is 2–3%. The composition of strychnine in these species rangesbetween 1% and 3%. Strychnine is widelyknown as a poison. Its therapeutic applica tions are very limited. It is used as a rodentpoison.

• Verwenden

  Destroying rodents and predatory animals.

• Verwenden

  central stimulant

• Verwenden

  Strychnine is used for the control of moles, squirrels, rabbits, gophers, mice and other small rodents and of bird pests. Rats normally avoid the bait.

• Indications

  Strychnine is clinically used for the treatment of barbiturate poisoning, hemiplegia, amblyopia, blood diseases, and streptomycin toxicity. Strychnine is used to treat aplastic anemia.

• Vorbereitung Methode

  Strychnine is extracted from Strychnos nux-vomica seeds. The very complex chemical synthesis has been achieved by WOODWARD et al. (74).

• Definition

  strychnine: A colourless poisonouscrystalline alkaloid found in certainplants.

• Definition

  ChEBI: Strychnine is a monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position. It has a role as an avicide, a glycine receptor antagonist, a cholinergic antagonist, a rodenticide and a neurotransmitter agent. It is a monoterpenoid indole alkaloid and an organic heteroheptacyclic compound. It is a conjugate base of a strychnine(1+). It derives from a hydride of a strychnidine.

• Weltgesundheitsorganisation (WHO)

  Strychnine, the principal alkaloid present in nux vomica, was first used in medicine several centuries ago. However, it has no demonstrated therapeutic value and there is no current justification for its presence in any medication. It continues to be used as a rodenticide though such use is severely restricted in many countries since accidental ingestion can be lethal.

• Allgemeine Beschreibung

  Colorless, transparent crystals or white crystalline powder. Has no odor. Used for destroying rodents and predatory animals and for trapping fur-bearing animals.

• Reaktivität anzeigen

  STRYCHNINE is an alkaloid derivative. STRYCHNINE is a base and forms water soluble salts with acids. Avoid alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light. [EPA, 1998]. STRYCHNINE is incompatible with the following: Strong oxidizers .

• Hazard

  Toxic by ingestion and inhalation. Central nervous system impairment.

• Health Hazard

  Super toxic; probable oral lethal dose in humans is less than 5 mg/kg, a taste (less than 7 drops) for a 70 kg (150 lb.) person. It causes violent generalized convulsions. Death results from respiratory arrest as the respiratory muscles are in sustained spasm. The lowest lethal oral dose reported for humans is 30 mg/kg.

• Health Hazard

  Strychnine is a highly toxic alkaloid. Itcauses hypersensitivity to sensory stimuli.It is a powerful convulsant. This results inrespiratory and metabolic acidosis (Hodgson et al. 1988). Death occurs from asphyxiaafter a few seizures. Its convulsant actionsare attributed to the antagonism of theinhibitory effects of glycine. It excites allportions of the central nervous system. Itproduces green-colored vision, which is aneffect of sensory disorders. Toxic symptomsfrom continued medication with strychnineinclude photophobia, muscular rigidity, stiff ness in joints, lassitude, and headache (vonOettingen 1952, ACGIH 1986). Ingestion of0.1 g may be fatal to humans.
  LD50 value, oral (mice): 2 mg/kg
  Intravenous administration of diazepamis applied for the treatment of strychninepoisoning.

• Brandgefahr

  When heated, emits highly toxic fumes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. Protect from light.

• Landwirtschaftliche Anwendung

  Rodenticide, Avicide: Strychnine products are allowed for use only below ground where exposure to food and feed crops is not expected. It can be used in orchards, feed crop sites, pastures, range land, alfalfa fields, irrigation systems, non-agriculture rights-of-way, forests, and residential sites. Pocket gophers are primary targets. Not listed for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP)

• Handelsname

  BOOMER-RID®; CERTOX®; DOLCO MOUSE CEREAL®; GOPHER BAIT®; GOPHERGETTER®; GOPHER-GO AG BAIT®; HARE-RID®; KWIK-KIL®; MOLE DEATH®; MOUSE-NOTS®; MOUSE-RID®; MOUSE-TOX®; NUX VOMICA®; PIED PIPER MOUSE SEED® (strychnine); RO-DEX®; SANASEED®

• Pharmakologie

  The pharmacological effect of strychnine is mainly manifested in the central nervous system, cardiovascular system, digestive system and antitumor effects.
  Studies have shown that the effects of strychnine on the nervous system are mainly manifested in the following areas: (1) Strychnine can improve the excitability of the spinal cord. In the recovery period of acute myelitis patients, the nerve recovery is very slow. Strychnine can stimulate the reflex function of the spinal cord, improve the function of the sensory centers of cerebral cortex, and significantly speed up the recovery of nerve function of acute myelitis patients. (2) Strychnine can excite the medulla oblongata and improve the excitabilities of vascular movement center and respiratory center. (3) Strychnine can excite the cerebral cortex. The therapeutic dose of strychnine can excite the cerebral cortex, wake up the patients in the state of inhibition, and improve the functions of hearing, vision, taste, touch, and other receptors of patients.
  The treatment effects of strychnine on the arrhythmia. Strychnine is able to block the voltage-gated sodium channel Nav1.5, which is a major subtype of the voltagegated sodium (Nav) channel. Nav1.5 exists in cardiomyocytes of mammalian species and plays an important role in maintaining excitability of cardiomyocytes and excitability conduction. Studies have shown that strychnine can inhibit the Nav1.5 current in a concentration-dependent manner; therefore, it has a potential advantage in the treatment of arrhythmias.
  Strychnine can promote the digestive function through reflex. Strychnine can increase the gastric secretion through stimulation of the sensory receptors and promote digestion and appetite. In addition, 0.5?mM and 1?mM strychnine can significantly induce cell shrinkage after HepG2 exposure to strychnine for 72?h and can inhibit the proliferation of HepG2 cells and promote cell apoptosis, suggesting that strychnine may possess antitumor effects.

• Clinical Use

  Strychnine is commonly used in the treatment of flaccid paralysis, ENT diseases, diabetes, neurasthenia, acute myelitis, peripheral neuritis, and aplastic anemia in clinic. However, due to the relatively high toxicity of strychnine, excessive or longterm use of strychnine may lead to poison. Studies have shown that the combination of Strychnos and Glycyrrhiza or cinnamon can reduce the toxicity of strychnine. Therefore, further study of poisoning mechanism and toxicokinetics of strychnine is of great significance for the clinical safety

• Sicherheitsprofil

  Human poison by ingestion. Experimental poison by ingestion, intravenous, subcutaneous, and intraperitoneal routes. Experimental reproductive effects. An allergen. Lethal dose to man: 30-60 mg/kg. If ingested, the time of action depends upon the condition of the stomach, whether empty or full, and the nature of the food present. If taken by subcutaneous injection, the place of administration of the injection will affect the time of action. The first symptoms are a feeling of uneasiness with a heightened reflex of irritability, followed by muscular twitching in some parts of the body. With larger doses, this is followed by a sense of impending suffocation. Convulsive movements begin that have the effect of mechanically causing the patient to cry out or to shriek; then follow the characteristic spasms, which set in with violence. These are at first clonic and then tonic. There are successive attacks of spasms. With each successive attack, the symptoms become more violent, eventually resulting in death. A rodenticide. When heated to decomposition it emits toxic fumes of NOx.

• mögliche Exposition

  de, requiring a certified applicator. Strychnine is an alkaloid compound that has been widely used as a rodenticide/bait to kill rodents; a medicine, respiratory stimulant. A potential danger to those involved in the extraction the seeds of the Strychnos nux vomica, Strychnos ignatii (S. sancta Ingnatius), and Strychnos tiente (Upas tree); formulation or application of this rodent poison. The sulfate is used to kill gophers and moles. A common adulterant in illicit street drugs. Listed as a potential WMD biotoxin.

• Source

  Strychnine silver morning glory, wood rose, and in Strychnos nusvomica L.: 15,800, 400– 12,000, 8,000, and 7,030 ppm in bark, seeds, leaves, and roots, respectively (Duke, 1992).

• Environmental Fate

  Chemical/Physical. Reacts with acids forming water-soluble salts (Worthing and Hance, 1991). Emits toxic nitrogen oxides when heated to decomposition (Lewis, 1990).

• Stoffwechselwegen

  Strychnine is used for the control of rodents in field situations and experiments on its sorption and degradation in soil have been reported but with very little information specifically on metabolic pathways. Metabolism in rats has been conducted and this has been supported by studies in vitro using liver microsomes from several species. A picture of its metabolism has been established but further work on minor pathways and conjugation may be necessary.

• Solubility in water

  (g/L):
  Alcohol (6.67 g/L), amyl alcohol (4.55 g/L), benzene (5.56 g/L), chloroform (200 g/L), glycerol (3.13 g/L), methanol (3.85 g/L), toluene (≈ 5 g/L) (Windholz et al., 1983), pyridine (>12.3 g/kg at 20–25 °C) (Dehn, 1917)

• Versand/Shipping

  UN1692 Strychnine or strychnine salts, Hazard Class: 6.1; Labels: 6.1-Poisonous material.

• läuterung methode

  It crystallises from CHCl3/Et2O and sublimes at 125o/0.01mm. It can also be purified by conversion to the hydrochloride [m 275-295o (dec), []D -44o (0.03N HCl)] with aqueous HCl, then neutralisation with ammonia. [Beilstein 27 II 723, 27 III/IV 7530.] It is POISONOUS.

• Degradation

  Strychnine is a base which forms stable salts with inorganic acids, e.g. the hydrochloride and sulfate. It is hydrolytically stable at 25 °C with DT₅₀ values >31 days at pH 5,7 and 9 (PM).

• Inkompatibilitäten

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Dangerous when heated; forms toxic fumes, including nitrogen oxides. In the body, caffeine may increase the strychnine effect.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Careful incineration has been recommended for disposal. Two procedures are suggested. Pour or sift onto a thick layer of sand and soda ash mixture (90-10). Mix and shovel into a heavy paper box with much paper packing Burn in incinerator. Fire may be augmented by adding excelsior and scrap wood. Stay on the upwind side. Waste may be dissolved in flammable solvent (alcohols, benzene, etc.) and sprayed into fire box of an incinerator with afterburner and scrubber.

• Einzelnachweise

  Regnault., Annalen, 26, 17 (1838)
  Watson, Sen.,!. Ind. Chem. Soc., 3,397 (1926)
  Schwyzer., Die Fabrikation der Alkaloide, (Berlin, 1927)
  Leuchs, Beyer., Ber., 68, 290 (1935)
  Clemo., J. Chem. Soc., 1695 (1936)
  Briggs, Openshaw, Robinson., ibid, 903 (1946)
  Chakravarti, Robinson., Nature, 160, 18 (1947)
  Woodward., ibid, 162, 155 (1948)
  Woodward., Tetrahedron, 19,247 (1963)
  Nagarajan etal., Helv. Chim. Acta, 46, 1212 (1963)
  Sandberg et al., Tetrahedron Lett., 6217 (1968)
  Absolute configuration: Peerdemann., Acta Cryst., 9,824 (1956)
  Pharmacology: Lambruschini., Rev. Soc. argent. biol., 14, 353 (1938)
  Travell., J. Pharm. expo Ther., 69,21 (1940)
  Weigmann., Arch. expo Path. Pharm., 196, 521 (1940)
  Raymond-Hamet., Bull. sci. pharmacol., 48, 306 (I 941)
  Coppee, Coppee-Bolly., Arch. intern. physiol., 51,97 (1941)
  Abreu, Woodbury., J. Pharm. expo Ther., 78, 321 (1943)

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