Cyproheptadine hydrochloride sesquihydrate

Bezeichnung:Cyproheptadine hydrochloride sesquihydrate

CAS-Nr41354-29-4

Englisch Name:Cyproheptadine hydrochloride sesquihydrate

CBNumberCB6698685

SummenformelC21H24ClNO

Molgewicht341.88

MOL-Datei41354-29-4.mol

Cyproheptadine hydrochloride sesquihydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	165 °C (dec.)(lit.)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	ethanol: soluble
Aggregatzustand	solid
Farbe	white to slightly yellow
maximale Wellenlänge (λmax)	285nm(0.05mol/L H2SO4)(lit.)
Merck	14,2773
InChI	InChI=1S/C21H21N.ClH.H2O/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;/h2-11H,12-15H2,1H3;1H;1H2
InChIKey	PFQPCBUPUOPHGM-UHFFFAOYSA-N
SMILES	CN1CCC(=C2C3C=CC=CC=3C=CC3=CC=CC=C23)CC1.Cl.O
CAS Datenbank	41354-29-4(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	TM7050000
HazardClass	6.1
PackingGroup	III
HS Code	29333990
Speicherklasse	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Toxizität	LD50 orally in mice: 74.2 mg/kg (Loux)

Gefahreninformationscode (GHS)

Cyproheptadine hydrochloride sesquihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or slightly yellow, crystalline powder.
Verwenden
H1-antihistamine, antipruritic
Verwenden
Structural studies of an antihistimine
Verwenden
Cyproheptadine hydrochloride sesquihydrate has been used in:
- testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation
- the inhibition of 5-HT in in vivo and in vitro bioassays in crabs
- the inhibition of 5-HT in embryo physiological experiments
inhibition of calcitonin gene related peptide (CGRP)
Verwenden
Cyproheptadine is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. Cyproheptadine is a 5-HT2/5-HT1C serotonin receptor antagonist; H 1 histamine receptor antagonist; antipruritic.
Definition
ChEBI: The sesquihydrate of cyproheptadine hydrochloride. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate. A sedating antihistamine with antimuscarinic and calcium-channel blocking actions, it i used for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
Trademarks
Periactin (Merck).
Allgemeine Beschreibung
Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine. It induced preventive effect against the development of pergolide-induced valvulopathy in a rat model.
Biochem/physiol Actions
Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist, H1 histamine receptor antagonist and an antipruritic. The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder. Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs). Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders. Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.
Veterinary Drugs and Treatments
Cyproheptadine may be useful in cats as an appetite stimulant. It potentially may be of benefit in the treatment of feline asthma or pruritus in cats, but clinical experience is marginal for this indication.
Cyproheptadine is an antihistamine but its efficacy is questionable for this indication in dogs. The drug may be useful as adjunctive therapy for Cushing’s syndrome probably as result of its antiserotonin activity, however one study demonstrated efficacy in less than 10% of dogs treated for pituitary dependent hyperadrenocorticism.
Cyproheptadine may be useful as adjunctive treatment in dogs or cats with serotonin syndrome.
In horses, cyproheptadine has been used for treating photic head shaking and pars intermedia dysfunction (Equine Cushing’s Disease).

Cyproheptadine hydrochloride sesquihydrate Upstream-Materialien And Downstream Produkte

Cyproheptadine hydrochloride sesquihydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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