Lonidamin

Bezeichnung:Lonidamin

CAS-Nr50264-69-2

Englisch Name:Lonidamine

CBNumberCB6493965

SummenformelC15H10Cl2N2O2

Molgewicht321.16

MOL-Datei50264-69-2.mol

Synonyma

Lonidamin

Lonidamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	207-209°C
Siedepunkt	537.9±45.0 °C(Predicted)
Dichte	1.4835 (rough estimate)
Brechungsindex	1.6070 (estimate)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Soluble in DMSO (up to 25 mg/ml).
Aggregatzustand	solid
pka	3.00±0.10(Predicted)
Farbe	White
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey	WDRYRZXSPDWGEB-UHFFFAOYSA-N
CAS Datenbank	50264-69-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	60-22-40
S-Sätze:	53-22-36/37/39-45
WGK Germany	3
RTECS-Nr.	NK7886000
HS Code	29339900
Toxizität	LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood)

Gefahreninformationscode (GHS)

Lonidamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Lonidamine is an antineoplastic agent reportedly effective for the treatment of various cancers, including lung, breast, prostate and brain tumors. Its clinical effect appears to be associated with changes in cellular energy metabolism.
Originator
Angelini (Italy)
Verwenden
contraceptive, spermicidal
Definition
ChEBI: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.
Trademarks
Doridamina
Biologische Aktivität
Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro .
Biochem/physiol Actions
Inhibits the energy metabolism of neoplastic cells by interfering with hexokinase and disrupting uncoupler-stimulated mitochondrial electron transport; damages cell and mitochondrial membranes.
Lager
Room temperature
Einzelnachweise
1) Gatto?et al. (2002),?Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids; Contraception,?65?277 2) Floridi?et al., (1981),?Effect of Lonidamine on the Energy Metabolism of Ehrlich Ascites Tumor Cells; Cancer Res.,?41?4661 3) Ravagnan?et al. (1999),?Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore; Oncogene,?18?2537 4) Ben-Horin?et al. (1995),?Mechanism of Action of the Antineoplastic Drug Lonidamine: 31P and 13C Nuclear Magnetic Resonance Studies; Cancer Res.?55?2814 5) Nath?et al. (2016),?Mechanism of antineoplastic activity of lonidamine; Biochim.Biophys.Acta Reviews on Cancer?1866?151

Lonidamine Upstream-Materialien And Downstream Produkte

Lonidamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

50264-69-2, Lonidamine Verwandte Suche:

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