2-Amino-3-nitro-6-picoline

Bezeichnung:2-Amino-3-nitro-6-picoline

CAS-Nr21901-29-1

Englisch Name:2-Amino-3-nitro-6-picoline

CBNumberCB6493879

SummenformelC6H7N3O2

Molgewicht153.14

MOL-Datei21901-29-1.mol

2-Amino-3-nitro-6-picoline physikalisch-chemischer Eigenschaften

Schmelzpunkt	147-157 °C
Siedepunkt	276.04°C (rough estimate)
Dichte	1.3682 (rough estimate)
Brechungsindex	1.6500 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	2.50±0.50(Predicted)
Aggregatzustand	Crystalline Powder
Farbe	Yellow
Wasserlöslichkeit	Slightly soluble in water.
InChI	1S/C6H7N3O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3,(H2,7,8)
InChIKey	LCJXSRQGDONHRK-UHFFFAOYSA-N
SMILES	CC1=NC(N)=C([N+]([O-])=O)C=C1
CAS Datenbank	21901-29-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38-20/21/22
S-Sätze:	36/37/39-26-22-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29333990
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2

Gefahreninformationscode (GHS)

2-Amino-3-nitro-6-picoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S22:Staub nicht einatmen.
Chemische Eigenschaften
yellow crystalline powder
Verwenden
2-Amino-6-methyl-3-nitropyridine used as a intermediate in organic synthesis and used in medicine.
Synthese

1824-81-3

21901-29-1

Example 7: Synthesis of 6-(1-vinylimino)-2-carbamoyl-3-nitropyridine (Compound V) Reagents: (i) HNO3/H2SO4; (ii) NaNO2; (iii) POCl3; (iv) Na2Cr2O7; (v) SOCl2, followed by treatment with NH4OH; (vi) aziridine. Steps for the synthesis of compound 24: 1. cool concentrated sulfuric acid (100 mL) in an ice bath and slowly add raw compound 23 (30 g, 0.28 mol), keeping the temperature at 0°C. 2. 42 mL of a mixture of concentrated sulfuric acid (98%) and concentrated nitric acid (72%) with a volume ratio of 1:1 was added slowly dropwise, maintaining the reaction temperature at 0 °C. The reaction was allowed to stand for 12 hours after 1 hour. 3. The reaction mixture was poured into 2 L of ice-water mixture, the pH was adjusted to 7 with a strong aqueous alkali solution and filtered. 4. The filter cake was dried to obtain 54 g of crude product. 5. The crude product was subjected to hydrodistillation to obtain a bright yellow liquid. 6. The distillate was extracted with ethyl acetate and subsequently recrystallized in ethanol to give 12.5 g of compound 24 with a melting point of 156.5-158.5 °C (ethyl acetate) in 29% yield.
Einzelnachweise
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 6, p. 1331 - 1338
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 11
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 22, p. 3171 - 3176
[4] Patent: EP1479681, 2004, A1. Location in patent: Page 122
[5] Patent: US2002/32187, 2002, A1

2-Amino-3-nitro-6-picoline Upstream-Materialien And Downstream Produkte

2-Amino-3-nitro-6-picoline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

21901-29-1, 2-Amino-3-nitro-6-picoline Verwandte Suche:

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