6-Methyl-2-pyridylamin

Bezeichnung:6-Methyl-2-pyridylamin

CAS-Nr1824-81-3

Englisch Name:2-Amino-6-methylpyridine

CBNumberCB3853241

SummenformelC6H8N2

Molgewicht108.14

MOL-Datei1824-81-3.mol

Synonyma

6-Methyl-2-pyridylamin

6-Methyl-2-pyridylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	40-44 °C(lit.)
Siedepunkt	208-209 °C(lit.)
Dichte	1.0275 (estimate)
Brechungsindex	1.5560 (estimate)
Flammpunkt	218 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Aggregatzustand	Crystalline Low Melting Solid
pka	pK1: 7.41(+1) (25°C)
Farbe	Yellow
Wasserlöslichkeit	very faint turbidity
Sensitive	Hygroscopic
BRN	107048
InChIKey	QUXLCYFNVNNRBE-UHFFFAOYSA-N
CAS Datenbank	1824-81-3(CAS DataBase Reference)
NIST chemische Informationen	2-Pyridinamine, 6-methyl-(1824-81-3)
EPA chemische Informationen	2-Pyridinamine, 6-methyl- (1824-81-3)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25-36/37/38-24/25-23/24/25-24
S-Sätze:	26-36/37/39-45-37/39-28A
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	US1885000
F	10-21
TSCA	Yes
HazardClass	6.1
PackingGroup	II
HS Code	29333999

Gefahreninformationscode (GHS)

2-Amino-6-methylpyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R24/25:Giftig bei Berührung mit der Haut und beim Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
YELLOWISH CRYSTALLINE LOW MELTING SOLID
Verwenden
2-Amino-6-methylpyridine is a reagent used in the identification of selective inhibitor for phosphatidylinositol 3-kinase (PI3Ka).
Verwenden
Intermediate.
Definition
2-amino-6-methylpyridine, a colorless organic crystalline solid, is a prominent candidate to be exploited for the manufacturing of valuable compounds with biological activity. This synthetic nucleus can be used as precursor for the construction of diversified valuable scaffolds, e.g., 5-methyl-2-phenyl-3H-imidazo[4,5-b]pyridine and 6?bromo-5-methyl-2-phenylthiazolo[4,5-b]pyridine. The nitration of this nucleus in the presence of H2SO4 can yield N-(6-methyl-5-nitropyridin-2-yl)nitramide. It is also an important precursor for the generation of N-linked aminopiperidine-based gyrase inhibitors where during the course of reactions bromination of this nucleus was performed. Importantly, the amino group can be replaced by different halogen atoms, i.e. F, Cl, Br, or even by a nitroso group. Additionally, the methyl group on an aromatic system can be modified to the routine functional groups like aldehyde and carboxylic acid, or even bromination can be performed on this particular carbon[1].
Application
2-Amino-6-methylpyridine (2A6MPy) can be used as an electron donor and reacts with the π-acceptors tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 2,4,4,6-tetrabromo-2,5-cyclohexanediene dione (TBCHD) to form a solid charge transfer molecule in chloroform at 25 ℃. complex (CT), and the chemical formulae of the solid CT complexes were [(2A6MPy)(TCNE)2], [(2A6MPy)2(DDQ)], [(2A6MPy)4(TBCHD)], respectively^[2].
läuterung methode
Crystallise it three times from acetone and dry it under vacuum at ca 45o. Alternatively, keep it in contact with NaOH pellets for 3hours, with occasional shaking, decant and fractionally distil it [Mod et al. J Phys Chem 60 1651 1956]. It also recrystallises from CH2Cl2 on addition of pet ether. [Marzilli et al. J Am Chem Soc 108 4830 1986, Beilstein 22/9 V 210.]
Einzelnachweise
[1] Ali A, et al. 2-Amino-6-methylpyridine based co-crystal salt formation using succinic acid: Single-crystal analysis and computational exploration. Journal of Molecular Structure, 2021; 1230: 129893.
[2] SHERZOD MADRAHIMOV . Electronic, infrared, mass spectrometry and thermal studies on the reaction of 2-amino-6-methylpyridine with π-acceptors[J]. Journal of Molecular Structure, 2020. DOI:10.1016/j.molstruc.2019.127021.

2-Amino-6-methylpyridine Upstream-Materialien And Downstream Produkte

6-Methyl-2-pyridylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1824-81-3, 2-Amino-6-methylpyridine Verwandte Suche:

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