Glutathion

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Glutathione Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R68:Irreversibler Schaden möglich.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Beschreibung

  Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

• Chemische Eigenschaften

  White cryst. powder

• Originator

  L-Glutathione,Solgar,USA

• Verwenden

  glutathione is a peptide composed of cysteine, glycine, and glutamate. It is believed to enhance the skin’s cellular metabolism and oxygen utilization. It has been found to protect the fibroblast against free radical-induced oxidation and act as a powerful antioxidant. Studies indicate that it can inactivate the tyrosinase enzyme and quench free radicals that contribute to tyrosinase and melanin formation, thereby serving as a skin-lightening or de- pigmenting agent. glutathione is a component of plant and animal tissue, naturally occurring in the body and essential for the proper functioning of the immune system.

• Verwenden

  L-Glutathione is used in the treatment of lung diseases for patients who are HIV positive. It protects the cancerous cells by conferring resistance to chemotherapeutic drugs. It is involved in many aspects of metabolism including transport of g-glutanyl amino acids and reductive cleavage of disulfide bonds. As an antioxidant, it prevents damage to important cellular components that arise due to reactive oxygen species like free radicals and peroxide. It is also used to decrease the concentrations of inflammatory cytokines (IL-6, IL-18) as well as involved in increasing the level of serum Ca2+ ions. It is also used in white wine production.

• Definition

  ChEBI: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.

• Manufacturing Process

  The tripeptide thiol glutathione (L-γ-glutamyl-L-cysteinyl-glycine (GSH)) found in virtually all cells functions in metabolism, transport and cellular protection.
  Glutathione may be obtained from an yeast or synthetically.
  A yeast containing 600 parts of yeast solids is heated just to the boiling point of water. The yeast solids are removed by centrifuging or filtration. Sulphuric acid is added to the filtrate to give 0.5 N strength as sulphuric acid 6 parts of ascorbic acid are added. Then 2 parts of cuprous oxide are added with stirring. The reaction mixture is then centrifuged and washed until the precipitate is free from sulphates. The precipitate is suspended in 100 parts of water and hydrogen sulfide is bubbled through the water until all of the copper is precipitated as copper sulphide. The filtrate is evaporated and the glutathione is purified by recrystallization from 50% ethanol. All parts are by weight.
  The preparation of glutathion by methods of peptide synthesis is expansive and gives 20-30% yield of GHS. For the first time synthetic glutathion was prepared by M. Bergmann et al.

• Therapeutic Function

  Anabolic, Antidote

• benefits

  Glutathione contentin human blood is 26～34mg/100g,scavenging free radical, anti-oxidant, whiteningand spot-removing.Its recommended dosage in skin care products is 0.5~2%.

• Allgemeine Beschreibung

  Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signaling and protection against oxidative stress.
  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

• Biochem/physiol Actions

  Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.

• Sicherheitsprofil

  Moderately toxic by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.

• target

  DNA/RNA Synthesis | HIV | Immunology & Inflammation related

• Lager

  Store at +4°C

• läuterung methode

  Crystallise L-glutathione from 50% aqueous EtOH, dry it in a vacuum and

Glutathione Upstream-Materialien And Downstream Produkte

Glutathion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(1133)Suppliers

70-18-8, Glutathione Verwandte Suche: