Dinoproston Produkt Beschreibung

Prostaglandin E2  Struktur
363-24-6
  • CAS-Nr.363-24-6
  • Bezeichnung:Dinoproston
  • Englisch Name:Prostaglandin E2
  • Synonyma:Dinoproston
    PGE2;l-pge2;prostin;Propess;U 12062;Cervidil;Prepidil;prostine2;Prostenon;Cerviprost
  • CBNumber:CB8461799
  • Summenformel:C20H32O5
  • Molgewicht:352.47
  • MOL-Datei:363-24-6.mol
Dinoproston physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :66-68 °C
  • alpha  :-85.5 º (c=1, C2H5OH)
  • Siedepunkt: :406.07°C (rough estimate)
  • Dichte :1.0601 (rough estimate)
  • Brechungsindex :1.6120 (estimate)
  • storage temp.  :-20°C
  • Löslichkeit :ethanol: 1 mg/mL
  • pka :pKa 4.77± 0.09(H2O,t=25±0.1,I=0.1(NaCl)) (Uncertain)
  • Aggregatzustand :powder
  • Farbe :Clear yellow to amber
  • Wasserlöslichkeit :insoluble
  • Merck  :14,7877
  • BRN  :4709356
  • InChIKey :XEYBRNLFEZDVAW-ARSRFYASSA-N
  • CAS Datenbank :363-24-6(CAS DataBase Reference)
Sicherheit

Prostaglandin E2 Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R60:Kann die Fortpflanzungsfähigkeit beeinträchtigen.
    R22:Gesundheitsschädlich beim Verschlucken.
  • S-Sätze Betriebsanweisung: S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
    S22:Staub nicht einatmen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
  • Chemische Eigenschaften White to pale yellowish-cream powder
  • Originator Prostin E2,Upjohn,UK,1972
  • Verwenden The most common and most biologically potent of mammalian prostaglandins. Isolated from sheep prostate. Oxytocic; abortifacient.
  • Definition ChEBI: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostagland ns.
  • Manufacturing Process Hexamethyldisilazane (1 ml) and trimethylchlorosilane (0.2 ml) are added with stirring to a solution of PGA2 (250 mg) in 4 ml of tetrahydrofuran at 0°C under nitrogen. This mixture is maintained at 5°C for 15 hours. The mixture is then evaporated under reduced pressure. Toluene is added and evaporated twice. Then the residue is dissolved in 6 ml of methanol, and the solution is cooled to -20°C. Hydrogen peroxide (0.45 ml; 30% aqueous) is added. Then, 1N sodium hydroxide solution (0.9 ml) is added dropwise with stirring at - 20°C. After 2 hours at -20°C, an additional 0.3 ml of the sodium hydroxide solution is added with stirring at -20°C. After another hour in the range -10°C to -20°C, an additional 0.1 ml of the sodium hydroxide solution is added. Then, 1.5 ml of 1 N hydrochloric acid is added, and the mixture is evaporated under reduced pressure. The residue is extracted with ethyl acetate, and the extract is washed successively with 1 N hydrochloric acid and
    ine, dried with anhydrous sodium sulfate and evaporated. The residue is dissolved in 5 ml of diethyl ether. To this solution is added 0.5 ml of methanol and 0.1 ml of water. Amalgamated aluminum made from 0.5 g of aluminum metal is then added in small portions during 3 hours at 25°C. Then, ethyl acetate and 3 N hydrochloric acid are added, and the ethyl acetate layer is separated and washed successively with 1 N hydrochloric acid and
    ine, dried with anhydrous sodium sulfate, and evaporated. The residue is chromatographed on 50 g of acid-washed silica gel, eluting first with 400 ml of a gradient of 50- 100% ethyl acetate in Skellysolve B, and then with 100 ml of 5% methanol in ethyl acetate, collecting 25 ml fractions. Fractions 9 and 10 are combined and evaporated to give 18 mg of 11β-PGE2. Fractions 17-25 are combined and evaporated to give 39 mg of PGE2.
  • Trademarks Cervidil (Controlled Therapeutics); Prepidil (Pharmacia & Upjohn); Prostin E2 (Pharmacia & Upjohn);Minprostin;Prostaglandin;Prostarmon e;Prostin vr pediatric.
  • Therapeutic Function Oxytocic, Abortifacient
  • Weltgesundheitsorganisation (WHO) Dinoprostone, prostaglandin E2, was introduced into medicine in 1971 and is primarily used for cervical ripening during the induction of labour. It is available in various formulations for oral, parenteral and vaginal administration. Tablets, ampoules and vaginal dosage forms (tablets, pessaries, gel) remain registered in many countries.
  • Allgemeine Beschreibung PGE2 Dinoprostone (Prostin E2;Cervidil) is a naturally occurring prostaglandin that is administeredin a single dose of 10 mg by controlled-release(0.3 mg/hr) vaginal insert to induce cervical ripening. Use ofthis agent will potentiate the effects of oxytocin.
  • Biologische Aktivität Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP 1 , EP 2 , EP 3 and EP 4 receptors (K d values range between ~ 1-10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis.
  • Sicherheitsprofil Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by intravenous, intraplacental, and intravaginal routes: changes in the uterus, cervix and vagina; termination of pregnancy; and changes in ferthty. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Prostaglandin E2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Dinoproston Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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363-24-6, Prostaglandin E2 Verwandte Suche:
  • DINOPROSTONE
  • 7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoicaci
  • dinoproston
  • l-5-heptenoicaci
  • l-7-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoicacid
  • l-pge2
  • l-prostaglandine2
  • prostin
  • prostine2
  • 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid
  • (5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID
  • [5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID
  • [5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID
  • PROSTAGLANDIN
  • PROSTAGLANDIN E2
  • PROSTAGLANDINS E2
  • PGE2
  • (15s)-prostaglandine2
  • (5z,11-alpha,13e,15s)-11,15-dihydroxy-9-oxo-prosta-13-dien-1-oicacid
  • 11,15-dihydroxy-9-oxo-,(5z,11-alpha,13e,15s)-prosta-13-dien-1-oicacid
  • PROSTAGLANDIN E2 CELL CULTURE TESTED
  • PROSTAGLANDIN E2 GAMMA-IRRADIATED*CELL C ULTURE TEST
  • PROSTAGLANDIN,PGE2
  • Dinoprostol
  • 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID
  • 7-(3-HydroxyProsta-5,13-dien-1-oic acid, (5Z,11-alpha,13E,15S)-11,15-dihydroxy-9-oxo-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-5-heptenoic acid
  • [5Z,11R,13E,15S,(-)]-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
  • Prostaglandin E2,98%
  • [5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROS
  • Prostaglandin E2,(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, PGE2
  • Dinoprostone (50 mg) (COLD SHIPMENT REQUIRED)
  • cGMP Dinoprostone
  • Prostaglandin E2 Lipid Maps MS Standard
  • (5Z,11α,13E,15S)-
  • CervidilProstaglandin E2
  • (5z,11α,13e,15s)-11,15-dihydroxy-9-oxoprosta-5,13-dienoic acid
  • (E)-7-[(1S,2S,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid
  • 11α,15α-Dihydroxy-9-ketoprosta-5,13-dienoic acid
  • 11α,15α-Dihydroxy-9-oxo-5-cis,13-trans-prostadienoic acid
  • 5-Heptenoic acid, 7-[3a-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- (7CI)
  • Cervidil
  • Cerviprost
  • Enzaprost E
  • Minprositin E2
  • Minprostin E2
  • NSC 165560
  • NSC 196514
  • Prepidil
  • Propess
  • Prostarmon E
  • Prostenon
  • Prostenone
  • Prostin (prostaglandin)
  • U 12062
  • PGE2, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
  • Dinoprostone, PGE2, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
  • (5Z,11α,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
  • Dinoprostone PGE2