Icosa-5,8,11,14-tetraensure

Bezeichnung:Icosa-5,8,11,14-tetraensure

CAS-Nr506-32-1

Englisch Name:Arachidonic acid

CBNumberCB8112259

SummenformelC20H32O2

Molgewicht304.47

MOL-Datei506-32-1.mol

Synonyma

Icosa-5,8,11,14-tetraensure

Icosa-5,8,11,14-tetraensure physikalisch-chemischer Eigenschaften

Schmelzpunkt	-49 °C (lit.)
Siedepunkt	169-171 °C/0.15 mmHg (lit.)
Dichte	0.922 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.4872(lit.)
Flammpunkt	>230 °F
storage temp.	2-8°C
Löslichkeit	ethanol: ≥10 mg/mL
pka	4.75±0.10(Predicted)
Aggregatzustand	oil
Farbe	colorless to light yellow
Wasserlöslichkeit	PRACTICALLY INSOLUBLE
Merck	14,765
BRN	1713889
Concentration	1 mCi/ml
Solvent	Ethanol under argon
Specific Activity	200-240 Ci/mmol
Stabilität	Light Sensitive, Temperature Sensitive
InChIKey	YZXBAPSDXZZRGB-DOFZRALJSA-N
LogP	6.99
CAS Datenbank	506-32-1(CAS DataBase Reference)
NIST chemische Informationen	Arachidonic acid(506-32-1)

Sicherheit

R-Sätze:	19
S-Sätze:	24/25-19
RIDADR	UN1170 - class 3 - PG 2 - Ethanol
WGK Germany	3
RTECS-Nr.	CE6675000
F	8-10-23
HS Code	29161900
Toxizität	dns-mus:mmr 10 mg/L CRNGDP 5,1123,84

Gefahreninformationscode (GHS)

Arachidonic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R19:Kann explosionsfähige Peroxide bilden.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).
Chemische Eigenschaften
In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.
Chemische Eigenschaften
liquid
Verwenden
arachidonic acid is an ingredient with skin-smoothing, emollient, and healing properties. Arachidonic acid is an omega-6 essential fatty acid naturally occurring in the skin and considered critical for appropriate skin metabolism. It is a constituent of vitamin F.
Verwenden
Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.
Verwenden
An unsaturated omega-6 fatty acid constituent of the phospholipids of cell membranes
Definition
ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
Allgemeine Beschreibung
A Certified Spiking Solution^? suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.
Biologische Aktivität
Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
Biochem/physiol Actions
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
Sicherheitsprofil
Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.
Carcinogenicity
In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.

Arachidonic acid Upstream-Materialien And Downstream Produkte

Icosa-5,8,11,14-tetraensure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

506-32-1, Arachidonic acid Verwandte Suche:

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