N-Glycylglycin

Bezeichnung:N-Glycylglycin

CAS-Nr556-50-3

Englisch Name:Glycylglycine

CBNumberCB3704259

SummenformelC4H8N2O3

Molgewicht132.12

MOL-Datei556-50-3.mol

Synonyma

N-Glycylglycin

N-Glycylglycin physikalisch-chemischer Eigenschaften

Schmelzpunkt	220-240 °C (dec.)
Siedepunkt	267.18°C (rough estimate)
Dichte	1.5851 (rough estimate)
Dampfdruck	0.058Pa at 20-50℃
Brechungsindex	1.4880 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit	H₂O: 1 M at 20 °C, clear, colorless
Aggregatzustand	Solid
pka	3.139(at 25℃)
Farbe	White
PH	4.5-6.0 (20℃, 1M in H2O)
Säure-Base-Indikators(pH-Indikatoren)	7.5 - 8.9
Wasserlöslichkeit	SOLUBLE IN HOT WATER
maximale Wellenlänge (λmax)	λ: 260 nm Amax: 0.075 λ: 280 nm Amax: 0.072
Merck	14,4503
BRN	1765223
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	YMAWOPBAYDPSLA-UHFFFAOYSA-N
LogP	-0.92 at 25℃ and pH6
CAS Datenbank	556-50-3(CAS DataBase Reference)
NIST chemische Informationen	N-Glycylglycine(556-50-3)
EPA chemische Informationen	Glycylglycine (556-50-3)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	24/25-26
WGK Germany	3
F	10
TSCA	Yes
HS Code	29241900

Gefahreninformationscode (GHS)

Glycylglycine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White crystals
Verwenden
Glycylglycine is as a buffering reagent and also used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. It is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption.
Definition
ChEBI: A dipeptide formed from glycine residues.
Synthesis Reference(s)
Journal of the American Chemical Society, 75, p. 5323, 1953 DOI: 10.1021/ja01117a053
Biochem/physiol Actions
Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine.
läuterung methode
Crystallise glycylglycine from aqueous 50% EtOH or water at 50-60o by addition of EtOH. Dry it at 110o. It sublimes at 190-200o/0.3mm with 30% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955, King J Am Chem Soc 79 6153 1957]. [Beilstein 4 IV 2459.]

Glycylglycine Upstream-Materialien And Downstream Produkte

N-Glycylglycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

556-50-3, Glycylglycine Verwandte Suche:

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