Sulfathiazol

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

  H412：Schädlich für Wasserorganismen, mit langfristiger Wirkung.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P273：Freisetzung in die Umwelt vermeiden.

  P302+P352：BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Sulfathiazole Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Chemische Eigenschaften

  white to cream powder

• Originator

  Tiazol,C. and C.

• Verwenden

  Antibacterial.This compound is a contaminant of emerging concern (CECs).

• Verwenden

  Sulfonamide antibacterial.

• Definition

  ChEBI: A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.

• Manufacturing Process

  116 parts 4-acetamidobenzolsufonyl chloride (prepared from acetanilide and chlorosulfonic acid) was mixed with 100 parts 2-aminothiasole in 1000 parts water by cooling and stirred for some hours. The bis-amide obtained was filtered off and re-crystallized from 50% ethanol to give bis-(pacetylaminobenzolsulfo)- 2-aminothiazol with MP: 129°C.
  10 parts above bis-amide was heated with 10% sodium hydroxide solution for 0.5 hour on water bath. On cooling and filtration the alkaline solution was acidified with glacial acetic acid. The amide obtained was cleared by recrystallized from water to give N1-2-thiazolylsulfanilamide; MP: 202°-203°C.

• Trademarks

  Argazol;Bucosol;Chemiovis;Coryza;Crionil;Csp 500;Csp-250;Edifeno;Femakzem;Formotablin antidiarreico;Gyne-sulf;Gyn-sulf;Neosutrin;Polvos wilfe;Pomada wilfe;Prothiazol;Septex cream no. 2;Streptacillin;Sulfa-orzon;Sulfazol;Sulfhatose;Sulfintestin;Sulfopyrol;Sulfour;Sulfzol;Sulnac;Sulphatriad;Tampovagan pss;Thiadyl;Thiuramide;Tiadyl;Trimeto;Trisulpha;Trysul;Tylasul;Ufa 902-duo;Vetoprim mi;Wintrazol.

• Therapeutic Function

  Antibacterial

• Weltgesundheitsorganisation (WHO)

  Sulfathiazole, a sulfonamide anti-infective agent, was introduced more than 25 years ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Although preparations remain available, use of the drug has been discontinued in many countries.

• Allgemeine Beschreibung

  White crystalline powder. Is dimorphous: form I is consists of prismatic rods and form II of six-sided plates and prisms. Insoluble in water and soluble in dil aqueous acid and aqueous base.

• Air & Water Reaktionen

  May be sensitive to heat, air and light during long-term storage . Insoluble in water.

• Reaktivität anzeigen

  Sulfathiazole is an amino acid.

• Brandgefahr

  Flash point data for Sulfathiazole are not available, but Sulfathiazole is probably combustible.

• Pharmazeutische Anwendungen

  2-Sulfanilamidothiazole. A short-acting compound (half-life c. 4 h) with relatively high activity. Protein binding is c. 75%. Its use has declined because of a high incidence of side effects. It is one of the constituents of triple sulfonamide mixtures, of which local preparations are still available.
  Two compounds, phthalylsulfathiazole (sulfathalidine) and succinylsulfathiazole (sulfasuxidine) owe their activity to the slow liberation of sulfathiazole in the bowel. They are poorly soluble and very little is absorbed after oral administration. They were formerly used in the treatment of intestinal infections and in bowel preparation before surgery. They are available in multi-ingredient preparations in some countries.

• Biochem/physiol Actions

  Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.Mode of Action: Inhibits folic acid synthesis in prokaryotes.Anti-microbial Spectrum: Gram positive, Gram negative, ChlamydiaMode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

• Sicherheitsprofil

  Human poison by unspecified route. Experimental poison by intraperitoneal route, Moderately toxic by intravenous, subcutaneous, and parenteral routes. Mildly toxic by ingestion. Human systemic effects by unspecified route: conjunctiva irritation, tubule changes, and allergic skin dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data, Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Sulfathiazole Upstream-Materialien And Downstream Produkte

Sulfathiazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(455)Suppliers

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