Phthalylsulfathiazol

Bezeichnung:Phthalylsulfathiazol

CAS-Nr85-73-4

Englisch Name:Phthalylsulfathiazole

CBNumberCB2405964

SummenformelC17H13N3O5S2

Molgewicht403.43

MOL-Datei85-73-4.mol

Synonyma

Phthalylsulfathiazol

Phthalylsulfathiazol physikalisch-chemischer Eigenschaften

Schmelzpunkt	198-204°C
Siedepunkt	371.31℃[at 101 325 Pa]
Dichte	1.4235 (rough estimate)
Dampfdruck	0Pa at 25℃
Brechungsindex	1.6390 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent).
pka	3.40±0.36(Predicted)
Farbe	White to Light Yellow
Wasserlöslichkeit	400mg/L at 28℃
Merck	14,7377
BRN	359901
LogP	-2 at 28℃
CAS Datenbank	85-73-4(CAS DataBase Reference)
NIST chemische Informationen	Phthalylsulfathiazole(85-73-4)
EPA chemische Informationen	Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- (85-73-4)

Sicherheit

S-Sätze:	24/25
RIDADR	3249
RTECS-Nr.	TH8575000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29350090
Toxizität	LD50 i.p. in mice: 920 mg/kg (Mattis)

Gefahreninformationscode (GHS)

Phthalylsulfathiazole Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White or yellowish-white, crystalline powder.
Originator
Sulfathalidine, MSD, US,1946
Verwenden
Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.
Definition
ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.
synthetische
It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.
It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.
Manufacturing Process
5 g of phthalic anhydride was added to a boiling suspension of 10 g of sulfathiazole in 100 cc of alcohol. The mixture was then refluxed for 5 minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water, The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-phthalylsulfanilamidothiazole,which decomposes above 260°C, according to US Patent 2,324,015.
Trademarks
Canidis-anti-diarr;Carbidiar;Carbotalin;Colicitina;Coliclase;Crematalil;Diacolin;Direver;Disenterol;Ef-micin;Enterocalme;Entero-hermes;Entero-red;Enterosteril;Entero-toxan;Esteraplidin mag;Eugeniteed;Fitazil;Ftalil-tiazol;Ilentazol;Inrestibla strepto;Iodentero-neomicina;Logical;Massotalil;Neo-sulfazon;Novosulfina;Phtazol;Septiftalil;Syptan;Talisulfazol;Tamil;.
Therapeutic Function
Antibacterial (intestinal)
Weltgesundheitsorganisation (WHO)
Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.
Flammability and Explosibility
Non flammable
Mode of action
Phthalylsulfathiazole is of low inherent toxicity. Besides, it also enjoys an additional plus point for being only slightly absorbed by the intestinal mucosa ; and, therefore, may be safely administered in comparatively large doses in the management and treatment of bacillary infections of the intestine. The drug is not absorbed orally and is mostly employed for ulcerative colitis.

Phthalylsulfathiazole Upstream-Materialien And Downstream Produkte

Phthalylsulfathiazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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