Penicillin G potassium salt

Bezeichnung:Penicillin G potassium salt

CAS-Nr113-98-4

Englisch Name:Penicillin G potassium salt

CBNumberCB4855484

SummenformelC16H17KN2O4S

Molgewicht372.48

MOL-Datei113-98-4.mol

Penicillin G potassium salt physikalisch-chemischer Eigenschaften

Schmelzpunkt	214-217 C
alpha	D22 +285° (c = 0.748 in water)
Brechungsindex	294 ° (C=1, H2O)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	H₂O: 100 mg/mL
Aggregatzustand	powder
Farbe	Needles from butanol (aq)
PH	pH (10g/L, 25℃) : 5.0～7.5
Wasserlöslichkeit	Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.
Merck	14,7094
BRN	3832841
Stabilität	Hygroscopic
InChIKey	IYNDLOXRXUOGIU-LQDWTQKMSA-M
SMILES	N12C([C@@H](NC(=O)CC3=CC=CC=C3)[C@@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O.[K+] \|&1:2,13,19,r\|
EPA chemische Informationen	Penicillin G Potassium (113-98-4)

Sicherheit

Kennzeichnung gefährlicher	Xn,C,F
R-Sätze:	42/43-34-11
S-Sätze:	36/37-45-36/37/39-26-16-60-37-24-22
WGK Germany	2
RTECS-Nr.	XH9700000
F	10-23
TSCA	Yes
HS Code	29411000
Toxizität	LD50 oral in rabbit: 5848mg/kg

Gefahreninformationscode (GHS)

Penicillin G potassium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R34:Verursacht Verätzungen.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
Beschreibung
Benzylpenicillin potassiumwas the first crystalline penicillin produced on an industrial scale , . It is produced in the pure state by the addition of phenylacetate to a culture of Penicillium chrysogenum. The crystalline benzylpenicillin potassium contains 1598 U/mg.
Chemische Eigenschaften
Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.
Verwenden
Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
Definition
ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).
synthetische
Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.
Trademarks
Pentids (Apothecon); Pfizerpen (Pfizer).
Allgemeine Beschreibung
Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
Biochem/physiol Actions
Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.
Sicherheitsprofil
Poison by intracerebral andintravenous routes. Moderately toxic by intraperitonealroute. Mutation data reported. See other penicillin entries.When heated to decomposition it emits toxic fumes ofNOx and SOx.

Penicillin G potassium salt Upstream-Materialien And Downstream Produkte

Penicillin G potassium salt Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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