3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenolhydrochlorid

Bezeichnung:3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenolhydrochlorid

CAS-Nr59263-76-2

Englisch Name:Meptazinol hydrochloride

CBNumberCB4843649

SummenformelC15H24ClNO

Molgewicht269.81

MOL-Datei59263-76-2.mol

Synonyma

3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenolhydrochlorid

3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenolhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	250-252°C
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	H2O: >10mg/mL
Aggregatzustand	powder
Farbe	white to off-white
Stabilität	Hygroscopic
InChIKey	MPJUSISYVXABBH-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	1
RTECS-Nr.	SL4250000

Gefahreninformationscode (GHS)

Meptazinol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Meptazinol hydrochloride is an injectable narcotic analgesic with antagonist properties; it is similar in potency to meperidine. Meptazinol appears to have a low propensity toward respiratory depression and other opiate-like side effects, possibly due to selective interaction with the mu-1 receptor. Also somewhat unique for an analgesic, it interacts with central cholinergic receptors. An oral form of meptazinol is under development.
Chemische Eigenschaften
White Solid
Originator
Wyeth (United Kingdom)
Verwenden
Mixed opioid agonist-antagonist. Analgesic (narcotic).
Verwenden
Analgesic;Opiate receptor agonist
Trademarks
MEPTID
Biologische Aktivität
Centrally active opioid analgesic. Partial agonist at the μ 1 opioid receptor. Also shown to inhibit acetylcholinesterase.
Biochem/physiol Actions
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.

Meptazinol hydrochloride Upstream-Materialien And Downstream Produkte

3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenolhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

59263-76-2, Meptazinol hydrochloride Verwandte Suche:

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