2-(Diethylamino)-1-phenyl-1-propanon-hydrochlorid

Bezeichnung:2-(Diethylamino)-1-phenyl-1-propanon-hydrochlorid

CAS-Nr134-80-5

Englisch Name:Amfepramone hydrochloride

CBNumberCB4676232

SummenformelC13H20ClNO

Molgewicht241.76

MOL-Datei134-80-5.mol

Synonyma

Amfepramonhydrochlorid

2-(Diethylamino)-1-phenyl-1-propanon-hydrochlorid

2-(Diethylamino)-1-phenyl-1-propanon-hydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	180-1810C
Flammpunkt	9℃
storage temp.	Controlled Substance, -20°C Freezer
Löslichkeit	DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
Aggregatzustand	A crystalline solid

Sicherheit

Kennzeichnung gefährlicher	F,T
R-Sätze:	11-23/24/25-39/23/24/25-20/21/22
S-Sätze:	7-16-36/37-45-36
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
HS Code	2922310000

Gefahreninformationscode (GHS)

Amfepramone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Solid
Originator
Tenuate,Merrell National ,US,1959
Verwenden
Controlled substance (stimulant). Anorexic.
Definition
ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.
Manufacturing Process
1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.
Therapeutic Function
Anorexic
Allgemeine Beschreibung
Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.

Amfepramone hydrochloride Upstream-Materialien And Downstream Produkte

2-(Diethylamino)-1-phenyl-1-propanon-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

134-80-5, Amfepramone hydrochloride Verwandte Suche:

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