Methylammoniumchlorid

Bezeichnung:Methylammoniumchlorid

CAS-Nr593-51-1

Englisch Name:Methylamine hydrochloride

CBNumberCB7122563

SummenformelCH5N.ClH

Molgewicht67.52

MOL-Datei593-51-1.mol

Synonyma

Methylammoniumchlorid

Methylammoniumchlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	231-233 °C(lit.)
Siedepunkt	225-230 °C15 mm Hg(lit.)
Dichte	0.8306 (rough estimate)
Dampfdruck	0.134Pa at 25℃
Brechungsindex	1.5500 (estimate)
Flammpunkt	225-230°C/15mm
storage temp.	Store below +30°C.
Löslichkeit	soluble
Aggregatzustand	powder
Farbe	White crystalline
Geruch (Odor)	Odorless
Säure-Base-Indikators(pH-Indikatoren)	5 - 7 at 10 g/l at 20 °C
PH	5-7 (10g/l, H2O, 20℃)
Wasserlöslichkeit	soluble
Sensitive	Hygroscopic
Merck	14,6014
BRN	3588822
Stabilität	Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents.
InChIKey	NQMRYBIKMRVZLB-UHFFFAOYSA-N
LogP	-3.82
CAS Datenbank	593-51-1(CAS DataBase Reference)
NIST chemische Informationen	Methylammonium chloride(593-51-1)
EPA chemische Informationen	Methylamine hydrochloride (593-51-1)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38
S-Sätze:	26-37/39
WGK Germany	1
RTECS-Nr.	PA0603000
F	10
TSCA	Yes
HS Code	29211190

Gefahreninformationscode (GHS)

Methylamine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Aussehen Eigenschaften
CH6ClN; Methylaminhydrochlorid. Farblose Kristalle mit schwachem Geruch.
Gefahren für Mensch und Umwelt
Reizt die Augen und die Atmungsorgane.
Resorption führt zu Herz-Kreislauf- und ZNS-Störungen.
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Staubschutz.
Verhalten im Gefahrfall
Trocken aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Wasser, Schaum.
Brennbar. Im Brandfall können Salzsäure und nitrose Gase entstehen.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Als feste Laborchemikalienabfälle.
Beschreibung
Methylamine Hydrochloride is a colorless organic solid that has an odor similar to that of fish and is used as an essential part for the synthesis of a wide variety of commercial compounds such as ephedrine, theophylline and other intermediates for a wide range of agricultural chemicals, including herbicides, fungicides, insecticides, biocides, and miticides. Methylamine hydrochloride is also a key ingredient in the synthesis of methamphetamine
Chemische Eigenschaften
white to light tan solid
Verwenden
Methylamine is used as a building block for the synthesis of other organic compounds. It is on the DEA watchlist for chemical precursors because of clandestine use in manufacture of the drug MDMA (ecstasy) and methamphetamine.
The HCl salt is in the form of white deliquescent crystals, and is frequently substitutable for the aq. soln. in many synthesis preparations. Methylamines are used directly as catalysts or as raw materials to produce other compounds with catalytic activity. Fuel additives are used to improve engine performance in a variety of ways. Trimethylamine is used to make paper chemicals. The manufacture of intermediates to make pharmaceuticals is one of the most diverse uses of methylamines.
synthetische
Methylamine hydrochloride is prepared by heating a mixture of aqueous formaldehyde and ammonium chloride; the residual water and the formic acid produced in the reaction are removed via vacuum distillation. This leaves behind solid methylamine hydrochloride. The solid is then purified by organic extractions and additional vacuum distillations. Methylamine gas for the reaction with P2P is generated in situ by heating the hydrochloride salt with sodium hydroxide. Alternatively, methylamine can be liberated from the hydrochloride with base and collected in a cold finger or flask immersed in a dry ice bath.
Application
Methylamine hydrochloride can be used as a reactant to synthesize:
Betahistine via aza-Michael reaction with 2-vinylpyridine in water.
Azatripyrrolic and azatetrapyrrolic macrocycles by reacting with pyrrole and formaldehyde via base-catalyzed Mannich reaction.
Tetrahydropyridines via Aza-Diels–Alder reaction with dienes and aldehydes.
N-methylsecondary arylamines from aryl chlorides via nickel-catalyzed amination reaction.
Definition
ChEBI: The hydrochloride formed from methylamine.
Pharmakologie
Methylamine hydrochloride reduces blood pressure in both normotensive and hypertensive individuals. It has a gradual onset of action (1/2 to 2 hours) and a long-lasting effect (usually 6 to 12 hours or more). A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced.
Solubility in organics
Very soluble in N,N-Dimethylformamide,Soluble in methanol,Sparingly soluble inglacial acetic acid, Very slightly soluble inchloroform.
Solubility in water
The experimental water solubility of Methylamine hydrochloride at 20 ℃ was 1080mg/L. Methylamine hydrochloride is highly soluble in water.
Lager
Keep in a dry, cool and well-ventilated place. Keep container tightly close
läuterung methode
Crystallise the salt from n-butanol, absolute EtOH or MeOH/CHCl3. Wash it with CHCl3 to remove traces of dimethylamine hydrochloride. Dry it under vacuum first with H2SO4 then P2O5. It is deliquescent; store it in a desiccator over P2O5. [Beilstein 4 IV 122.]

Methylamine hydrochloride Upstream-Materialien And Downstream Produkte

Methylammoniumchlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

593-51-1, Methylamine hydrochloride Verwandte Suche:

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