D-(+)-Maltose monohydrate

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

D-(+)-Maltose monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R33:Gefahr kumulativer Wirkungen.
  R63:Kann das Kind im Mutterleib möglicherweise schädigen.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Chemische Eigenschaften

  Maltose occurs as white crystals or as a crystalline powder. It is odorless and has a sweet taste approximately 30% that of sucrose.

• Chemische Eigenschaften

  White crystalline powder

• Verwenden

  D-(+)-Maltose monohydrate, is commonly found in foods and commonly utilized in brewing processes. It is also used in various culture media in the cell and tissue culture applications. D-(+)-Maltose Monohydrate is used as a substrate for α-glucosidase. It is also used as a substrate for the identification, differentiation and characterization of enzymes such as maltase(s); maltose α-D-glucosyltransferase(s); maltose-transporting ATPase(s); maltose O-acetyltransferase(s) and maltose epimerase(s) and phosphorylase(s). D-Maltose is used to study maltose-binding proteins and disaccharide transport systems.

• Verwenden

  D-Maltose, an α(1→4) linked disaccharide of D-glucose, is used as a substrate for the identification, differentiation and characterization of enzymes such as maltase(s); maltose α-D-glucosyltransferase(s); maltose-transporting ATPase(s); maltose O-acetyltransferase(s) and maltose epimerase(s) and phosphorylase(s). D-Maltose is used to study maltose-binding proteins and disaccharide transport systems.

• Verwenden

  A disaccharide commonly found in foods and commonly utilized in brewing processes.

• Vorbereitung Methode

  Maltose monohydrate is prepared by the enzymatic degradation of starch.

• Allgemeine Beschreibung

  Maltose monohydrate is commonly used as a tablet filler or excipient in pharmaceutical industry.
  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

• Pharmazeutische Anwendungen

  Maltose is a disaccharide carbohydrate widely used in foods and pharmaceuticals. In parenteral products, maltose may be used as a source of sugar, particularly for diabetic patients.
  Crystalline maltose is used as a direct-compression tablet excipient in chewable and nonchewable tablets.

• Biochem/physiol Actions

  Maltose is a disaccharide containing two glucose molecules with an α(1→4) glycosidic linkage. Maltose can be derived from starch in food through the action of amylase. Maltose can be found in many food products, including beer, cereals, and pasta.

• Sicherheit(Safety)

  Maltose is used in oral and parenteral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, there has been a single report of a liver transplantation patient with renal failure who developed hyponatremia following intravenous infusion of normal immunoglobulin in 10% maltose. The effect, which recurred on each of four successive infusions, resembled that of hyperglycemia and was thought to be due to accumulation of maltose and other osmotically active metabolites in the extracellular fluid.
  LD₅₀ (mouse, IV): 26.8 g/kg
  LD₅₀ (mouse, SC): 38.6 g/kg
  LD₅₀ (rabbit, IV): 25.2 g/kg
  LD₅₀ (rat, IP): 30.6 g/kg
  LD₅₀ (rat, IV): 15.3 g/kg
  LD₅₀ (rat, oral): 34.8 g/kg

• Lager

  Maltose should be stored in a well-closed container in a cool, dry place.

• läuterung methode

  Purify maltose by chromatography from aqueous solution on to a charcoal/Celite (1:1) column, wash it with water to remove glucose and other monosaccharides, then elute it with aqueous 75% EtOH. Crystallise it from water, aqueous EtOH or EtOH containing 1% nitric acid. Dry it as the monohydrate at room temperature under vacuum over H2SO4 or P2O5. Also purify it by dissolving it in MeOH, evaporating to a syrup which on standing for 12hours in contact with 1/10th its volume of H2O gives crystals of the monohydrate. Its iodine number is 55.5. The osazone has m 200o(dec) and [] D 20 +58o (c 1.4, H2O). [Howarth et al. J Chem Soc 793 1937, Beilstein 17 III/IV 3057, 17 V 189.]

• Inkompatibilitäten

  Maltose may react with oxidizing agents. A Maillard-type reaction may occur between maltose and compounds with a primary amine group, e.g. glycine, to form brown-colored products.

• Regulatory Status

  In the USA, maltose is considered as a food by the FDA and is therefore not subject to food additive and GRAS regulations. Included in the FDA Inactive Ingredients Database (oral solutions). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in parenteral products available in a number of countries worldwide.

D-(+)-Maltose monohydrate Upstream-Materialien And Downstream Produkte

D-(+)-Maltose monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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