Ethyltrifluormethansulfonat

Bezeichnung:Ethyltrifluormethansulfonat

CAS-Nr425-75-2

Englisch Name:Ethyl trifluoromethanesulfonate

CBNumberCB4332659

SummenformelC3H5F3O3S

Molgewicht178.13

MOL-Datei425-75-2.mol

Synonyma

Ethyltrifluormethansulfonat

Ethyltrifluormethansulfonat physikalisch-chemischer Eigenschaften

Siedepunkt	115 °C (lit.)
Dichte	1.374 g/mL at 25 °C (lit.)
Brechungsindex	n20/D 1.336(lit.)
Flammpunkt	96 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Chloroform, Methanol (Slightly)
Aggregatzustand	Oil
Farbe	Colourless
Wichte	1.374
Wasserlöslichkeit	Hydrolyzes in water.
Sensitive	Hygroscopic
BRN	1770746
Stabilität	Volatile
InChIKey	UVECLJDRPFNRRQ-UHFFFAOYSA-N
CAS Datenbank	425-75-2(CAS DataBase Reference)
EPA chemische Informationen	Methanesulfonic acid, trifluoro-, ethyl ester (425-75-2)

Sicherheit

Kennzeichnung gefährlicher	C,T,F
R-Sätze:	10-34
S-Sätze:	16-26-36/37/39-45
RIDADR	UN 2920 8/PG 2
WGK Germany	2
F	3
Hazard Note	Highly Toxic
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29049090

Gefahreninformationscode (GHS)

Ethyl trifluoromethanesulfonate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R10:Entzündlich.
R34:Verursacht Verätzungen.
S-Sätze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Ethyl trifluoromethanesulfonate is a cationic polymerization agent used to produce polyurethane, polyacrylate, and other synthetic resins. It is an effective drug for the treatment of HIV infection and chronic bronchitis. Ethyl trifluoromethanesulfonate has been shown to inhibit the replication of HIV-1 virus at concentrations as low as 1 μM when tested in vitro. The mechanism of this drug's anti-HIV activity is unknown and may involve the inhibition of reverse transcriptase or proteases. Ethyl trifluoromethanesulfonate can be detected in vivo up to 4 hours after administration. This drug is metabolized into trifluoroacetic acid by esterases, glycosidases, and/or oxidases.
Chemische Eigenschaften
Clear colorless to yellow liquid
Verwenden
Ethyl trifluoromethanesulfonate is a powerful ethylating agent. due to the strong electron-absorbing ability of trifluoromethanesulfonyl, the reactivity is much higher than that of conventional alkylation reagents such as bichloride or alkyl sulfonate.
Synthese
Triethyl orthoformate (4.44g,30mmol) was slowly added to trifluoromethanesulfonic anhydride (8.47g,30mmol) under ice bath, transferred to 25°C for reaction, monitored by NMR for 15 min, and the reaction was completed, distilled under reduced pressure to obtain 10.15g of ethyl trifluoromethanesulfonate colorless liquid in 94% yield.
läuterung methode
The ester reacts slowly with H2O and aqueous alkali. If its IR has no OH bands (~3000 cm-1) then purify it by redistillation. If OH bands are present, then dilute with dry Et2O and shake (carefully) with aqueous NaHCO3 until effervescence ceases, then wash with H2O and dry (MgSO4), filter, evaporate and distil the residue under a slight vacuum then at atmospheric pressure in a N2 atmosphere. IT IS A POWERFUL ALKYLATING AGENT, AND THE FUMES ARE VERY TOXIC — PERFORM ALL OPERATIONS IN AN EFFICIENT FUME CUPBOARD. [Gramstad & Haszeldine J Chem Soc 173 1956, Howells & McCown Chem Rev 77 69 1977, Beilstein 3 IV 34.]

Ethyl trifluoromethanesulfonate Upstream-Materialien And Downstream Produkte

Ethyltrifluormethansulfonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

425-75-2, Ethyl trifluoromethanesulfonate Verwandte Suche:

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