Flavoxathydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H335：Kann die Atemwege reizen.

Flavoxate hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Chemische Eigenschaften

  Flavoxate hydrochloride is Crystalline Solid

• Originator

  Urispas,SKF,US,1971

• Verwenden

  Smooth muscle relaxant. Used as antispasmodic; in treatment of urinary incontinence.

• Verwenden

  Antispasmodic;Phosphodiesterase inhibitor

• Definition

  ChEBI: The hydrochloride salt of flavoxate.

• Manufacturing Process

  A mixture of 13.3 grams of anhydrous aluminum chloride and 100 ml of carbon disulfide is added to 19.4 grams of 2-propionyloxybenzoic acid (prepared from the reaction of propionyl chloride and 2-hydroxybenzoic acid). After an initial evolution of hydrogen chloride, the solvent is removed by distillation and the mixture is heated at 150° to 160°C for 4 hours. The cooled reaction mixture is treated with ice and hydrochloric acid and the product, 2- hydroxy-3-carboxypropiophenone, is obtained from the oily residue by distillation in vacuo.
  A mixture of 1.9 grams of 2-hydroxy-3-carboxypropiophenone, 5.0 grams of sodium benzoate and 20.0 grams of benzoic anhydride is heated at 180° to 190°C for 6 hours. A solution of 15.0 grams of potassium hydroxide in 50 ml of ethanol and 20 ml of water is added and refluxed for 1 hour. The mixture is evaporated and the residue after addition of water yields 3-methylflavone-8- carboxylic acid.
  To a suspension of 12.0 grams of 3-methylflavone-8-carboxylic acid in 200 ml of anhydrous benzene is added 10.0 grams of thionyl chloride. The mixture is refluxed for 2 hours during which the suspended solid goes into solution. The solvent is completely removed by distillation, the residue extracted with benzene and the extract evaporated to dryness. The product, 3- methylflavone-8-carboxylic acid chloride, is recrystallized from ligroin to give crystals melting at 155° to 156°C.
  To 11.0 grams of 3-methylflavone-8-carboxylic acid chloride dissolved in 150 ml of anhydrous benzene is added at room temperature 4.8 grams of piperidinoethanol and the mixture refluxed for 2 to 3 hours. The separated solid is filtered, washed with benzene and dried. The product, piperidinoethyl 3-methylflavone-8-carboxylate hydrochloride is obtained as a colorless crystalline solid, MP 232° to 234°C, (from US Patent 2,921,070).

• Trademarks

  Urispas (Ortho-McNeil).

• Therapeutic Function

  Spasmolytic

• Nebenwirkungen

  The following adverse reactions have been observed, but there are not enough data to support an estimate of their frequency.
  Gastrointestinal: Nausea, vomiting, dry mouth.
  CNS: Vertigo, headache, mental confusion, especially in the elderly, drowsiness, nervousness.
  Hematologic: Leukopenia (one case which was reversible upon discontinuation of the drug).
  Cardiovascular: Tachycardia and palpitation.
  Allergic: Urticaria and other dermatoses, eosinophilia and hyperpyrexia.
  Ophthalmic: Increased ocular tension, blurred vision, disturbance in eye accommodation.
  Renal: Dysuria.

• Veterinary Drugs and Treatments

  Flovoxate may be considered for treating dogs with detrusor hyperspasticity (hyperactive bladder, urge incontinence).

• Pharmakologie

  Flavoxate hydrochloride counteracts smooth muscle spasm of the urinary tract and exerts its effect directly on the muscle. In a single study of 11 normal male subjects, the time to onset of action was 55 minutes. The peak effect was observed at 112 minutes. 57% of the flavoxate hydrochloride was excreted in the urine within 24 hours.

Flavoxate hydrochloride Upstream-Materialien And Downstream Produkte

Flavoxathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(337)Suppliers

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